Senior Scientist II (Preclinical Bioanalysis)

Exelixis•Alameda, CA

1d•Onsite

About The Position

The Senior Scientist II of preclinical bioanalysis provides preclinical bioanalytical support for the advancement of the biologics portfolio at Exelixis. The incumbent must have strong LCMS-based bioanalysis experience as s/he supports preclinical activities of ongoing and new projects in antibody drug conjugates and other biologics.

Requirements

Master’s degree in analytical chemistry or biology or closely related discipline and a minimum of seven (7) years of related experience; or PhD degree in analytical chemistry or biology or closely related discipline and a minimum of two (2) years of related experience is preferred; or Equivalent combination of education and experience.
Hand-on experience in assay development and sample analysis with LCMS-based bioanalytical assays for biologics is essential.
Scientific understanding of in vitro and in vivo pharmacology, PK, and PD concepts in cancer biology is important.
Demonstrated drive for rigorous scientific excellence.
Ability to think critically and creatively to identify and solve scientific problems.
Knowledge and familiarity in LC-MS-based bioanalysis is critical
Ability to work independently, good time management and organization skills.
Excellent written, oral, and interpersonal communication skills.
A strong team player.
Advanced knowledge in Excel, Word, PowerPoint, PDF, GraphPad prism.
Good tracking record and report writing.

Nice To Haves

Knowledge and experience of ligand-binding assays and metabolite ID is a plus

Responsibilities

Independently design and execute assay development and qualification of ADCs or other biologics in rodent and NHP matrices, perform pharmacokinetic sample analyses in support of proof-of-concept studies on biologic oncology programs from discovery to lead selection.
Design, implement and manage studies for pharmacokinetic characterization of biologic drug candidates conducted by CROs and in-house as needed.
Critical scientific/technical data analysis and interpretation of experiments.
Interact and collaborate with internal departments to deliver quality and timely findings in support of drug candidate advancement.
Effectively communicate scientific concepts, findings, and interpretation to multi-disciplinary teams.
Contribute to other translational biology efforts
Follow company intellectual property and compliance policies and practices.
Comply with company health and safety policies and general laboratory practices.