Senior Scientist I

WuXi AppTec•Cranbury Township, NJ

7d•Onsite

About The Position

Responsible to plan/perform/guide metabolite profiling and identification related DMPK studies and prepare study reports. This role involves identifying drug metabolites using advanced analytical techniques, elucidating metabolic pathways, and designing/conducting in vivo and in vitro metabolism studies. The scientist will handle radio-labeled materials and lead complex research projects, providing multiple approaches during the planning stage. This position also includes training, coaching, and mentoring others, as well as exercising independent judgment in developing methods and evaluation criteria. The role functions as a study director, principle investigator, or project coordinator, serving as a primary contact for sponsors and supervising personnel. The scientist will review other's work, write comprehensive reports, and present findings. Compliance with safety rules and company policies is essential. Continuous learning and sharing of technical knowledge in pharmaceutical areas, DMPK, ADME, In Life, Metabolism, and Bioanalysis is expected. Participation in writing and reviewing Standard Operating Procedures (SOPs) is also a responsibility. The job requires adherence to nonGLP guidelines/SOPs consistent with WuXi AppTec requirements.

Requirements

Doctorate Degree with >3 years related experience; Master's degree with >10 or BS> 14 years related experience or work equivalent experience.
Any similar combination of education and experience.
An expert in the use of advanced experimental methods, concepts and techniques relevant to scientific discipline and specific area of DMPK
Emerging skills in novel experimental methods, concepts and techniques
Demonstrates independent thought and scientific creativity
Demonstrates technical success and proficiency in projects
Utilizes expert knowledge of scientific principles and concepts
Collaboratively researches and proposes methodologies for projects
Acts independently to research and propose new research projects and methodologies and implement them
Good time management skills in order to perform multiple projects within deadlines
Expected to initiate external publications and presentations
Effective oral and written communication and interpersonal skills
Good time management skill in order to perform of multiple projects within deadlines
Ability to work in a team environment
Follow and adhere to nonGLP guidelines/SOPs consistent with WuXi AppTec requirement

Responsibilities

Identification of drug metabolites using liquid chromatography-tandem high-resolution accurate mass spectrometry, NMR, and other analytical methodologies.
Elucidates metabolic pathways involving the identification and quantification of metabolites in biological matrices (e.g., blood, plasma, excreta) more independently using HPLC with radioactivity detection and/or LC-MS/MS.
Designs, conducts, and guides in vivo and in vitro metabolism studies.
Handles radio-labeled materials (e.g., 3H, 14C).
Designs, plans and carries out the more complex research. Provides multiple approaches during the planning step.
Trains, coaches, or mentors others on technical, personal development or business issues.
Works on extremely complex problems in which analysis of situations or data requires an evaluation of intangible variables. Exercises independent judgment in developing methods, techniques and evaluation criteria for obtaining results.
Functions as a study director, principle investigator, or project coordinator including serving as a primary contact for sponsors, responsibilities include planning and supervising more complex and exacting research studies.
Supervises personnel. Ensures optimum personnel performance through leading by example, motivation, and performance recognition.
Reviews other scientists’ calculations, records, and reports. Writes comprehensive reports, recommending application of finings, and presents clear and concise oral reports of processes and accomplishments.
Complies with all safety rules, practice good housekeeping, and maintain safe workplace without supervision.
Learns, enhances, and shares technical knowledge of pharmaceutical areas, DMPK, ADME, In Life, Metabolism, and Bioanalysis.
Participates in writing and review of Standard Operating Procedures (SOPs) and suggest practical changes.
Follows company’s safety policies, practices and procedures in order to maintain a safe work environment.
Other duties as assigned.