Senior Scientist I, Process Development

LGC Group•Petaluma, CA

1d•Onsite

About The Position

The Senior Scientist in LGC Axolabs Process Development will serve as a subject matter expert (SME) in scale up/down solid-phase oligonucleotide synthesis, purification, concentration, conjugation, and downstream processing steps in preparation for handover to routine manufacturing. This role involves leading process development initiatives, providing technical guidance to cross-functional teams, and engaging with clients to ensure successful and timely execution of each assigned program. LGC Axolabs has an extensive, ever-evolving global client base along with impressive technical capabilities within a state-of-the-art GMP facility. As the needs for the organization continue to grow, we are seeking technically adept and highly motivated candidates who can contribute to innovative solutions in oligonucleotide process development. The successful candidate will be detail-oriented, proficient in advanced chemistry techniques, and experienced in oligonucleotide manufacturing. This role requires strong problem-solving skills, technical leadership, and direct interaction with clients to support their project needs.

Requirements

Bachelor’s degree in Chemistry, Biology, Biochemistry, or related discipline with 7+ years of applicable experience, or Master’s degree with 5+ years, or Ph.D. with 0–3 years of experience in a related field.
Advanced technical understanding of oligonucleotide manufacturing processes and hands-on experience with relevant chemistry techniques, equipment, and methods.
Strong communication skills, both written and verbal, to effectively collaborate with internal cross-functional teams and external partners.
Demonstrated dedication to scientific excellence and alignment with LGC’s core values and quality standards.
Proficiency in Microsoft Office, Outlook, Word, Filemaker Pro, IFS, and Excel.
Self-starter with strong problem-solving skills and the ability to work independently and with the broader team.
Ability to manage multiple development projects simultaneously while maintaining attention to detail and deliverable timelines.
Demonstrated commitment to scientific excellence and alignment with LGC’s core values and quality standards.

Nice To Haves

Technical understanding of oligonucleotide manufacturing processes and hands-on experience with relevant chemistry techniques, equipment, and methods.
Working knowledge of ChemDraw and Unicorn software (Synthesis and Purification).
Prior experience in a GMP-regulated environment within a CMO/CDMO or pharmaceutical manufacturing setting.

Responsibilities

Leading process development of all unit operations of custom oligonucleotide manufacturing including solid phase synthesis, cleavage and deprotection, preparative HPLC purification, conjugation chemistry, ultrafiltration/diafiltration, and lyophilization according to established project timelines.
Sample preparation of samples to the Analytical Development Team.
Technical support provided to the manufacturing team for relevant programs.
Serve as a subject matter expert (SME) in process development of oligonucleotide APIs, including research and implementation of novel techniques.
Independently design, execute, and interpret complex experiments, including use of DoE techniques.
Lead technical discussions with internal teams and clients to define development strategies, troubleshoot challenges, and drive project deliverables.
Author and review technical documentation, including client updates, project plans, QPPs, TDRs, and SOPs.
Collaborate with cross-functional teams (e.g., Analytical Development, Quality Control, and Manufacturing) to integrate development solutions into oligonucleotide production workflows.
Maintain working knowledge of relevant regulatory and pharmacopeia guidelines (FDA/ICH/USP) to ensure compliance across tech transfer activities.
Provide mentorship and technical guidance to junior scientists, supporting skill development and scientific excellence within the team.