Senior Scientist I or II, Oligonucleotide Chemistry and Innovation

Novartis•Cambridge, MA

1d•$93,800 - $174,200•Onsite

About The Position

What if your expertise could help shape the next generation of RNA medicines? At Novartis, we're advancing breakthrough xRNA therapeutics that have the potential to transform patients' lives, and we're looking for a talented scientist to help drive that mission forward. As a Senior Scientist in Oligonucleotide Chemistry and Innovation, you'll play a critical hands-on role in developing and optimizing therapeutic oligonucleotides, applying cutting-edge chemistry to solve complex scientific challenges. Working alongside a highly collaborative team of experts, you'll have the opportunity to influence scientific strategy, champion innovation, and contribute directly to pioneering therapies in a fast-paced and rewarding research environment.

Requirements

Bachelor of Science or Master of Science in Chemistry or a related scientific field.
Significant hands-on experience in oligonucleotide synthesis and conjugation within an academic or industry setting.
Demonstrated expertise using automated DNA and RNA synthesizer platforms.
Experience purifying and characterizing oligonucleotides using chromatographic and mass spectrometry techniques.
Strong data analysis, documentation, and scientific presentation skills.
Proven ability to thrive in a collaborative, fast-paced research environment while managing multiple priorities.

Nice To Haves

Doctor of Philosophy in Chemistry or a closely related scientific discipline.
Experience developing and optimizing methods incorporating specialty phosphoramidite building blocks.
Expertise with high-resolution liquid chromatography and mass spectrometry analytical techniques for oligonucleotide characterization.
Experience supporting the discovery and development of RNA therapeutics, including small interfering RNA and antisense oligonucleotides.
Exposure to high-throughput oligonucleotide synthesis workflows and process innovation.
Demonstrated ability to work independently with urgency, accountability, and strong organizational skills.

Responsibilities

Execute solid-phase synthesis of therapeutic oligonucleotides using automated DNA and RNA synthesizer platforms.
Purify and characterize oligonucleotides using chromatographic and mass spectrometry-based analytical techniques.
Develop and optimize synthesis, purification, and analytical methods to improve efficiency and product quality.
Operate, troubleshoot, and maintain critical laboratory instrumentation to ensure reliable data generation.
Identify and implement innovative oligonucleotide chemistries to advance RNA therapeutic discovery programs.
Analyze, interpret, and present experimental results to multidisciplinary scientific teams and stakeholders.
Maintain accurate electronic laboratory records and support reproducible, high-quality scientific practices.