Senior Scientist I, Host Cell Engineering

AbbVie•Worcester, MA

14h•Onsite

About The Position

We are seeking a highly-motivated Senior Scientist to join our multidisciplinary team focused on robust production cell lines to enable AbbVie’s clinical and commercial biologics pipeline. In this exciting lab-based position, the senior scientist will develop next generation mammalian host cell lines, leveraging advanced gene-editing technologies and System Biology knowledge to engineer CHO host cells for enhanced recombinant protein productivity, improved product quality, and streamlined process efficiency. In addition, the successful candidate will enable the Biologics’ pipeline through production cell line development and characterization and collaboration on cross-functional teams. Experience with cutting edge technologies such as CRISPR-Cas9, Cas-Clover, NGS, ‘Omics, bioinformatics, system biology, artificial intelligence (AI), machine learning (ML), HT automation, and digitalization for cell line and process optimization are highly preferred.

Requirements

Bachelor’s Degree in Scientific field with at least 10 years of related work; Master’s Degree in Scientific field with at least 8 years of related work; or PhD in Scientific field at least 0-2 years of related work experience.
Strong background in cell and molecular biology, with extensive experience with cell culture and aseptic technique.
Excellent problem-solving skills including critical and analytical thinking
Excellent communication, leadership, and project management skills.
Demonstrated scientific writing skills and strong verbal communication skills.
Demonstrated ability to independently design and execute experiments, interpret data, and identify appropriate follow-up strategies.
Proven track record of teamwork, adaptability, innovation, initiative, and integrity.
Global mindset to thrive in a diverse culture and environment
Interacts well with diverse groups within function and maintain strong working relationships with internal and external collaborators.
Ability to multitask and work within timelines in a dynamic fast-paced setting.

Nice To Haves

Experience with cutting edge technologies such as CRISPR-Cas9, Cas-Clover, NGS, ‘Omics, bioinformatics, system biology, artificial intelligence (AI), machine learning (ML), HT automation, and digitalization for cell line and process optimization are highly preferred.
Experience with ‘omics, genetic engineering, flow cytometry, fluorescence activated cell sorting (FACS), next generation sequencing, expression vector design, bioinformatics, systems biology, machine learning (ML), artificial intelligence (AI), and/or modeling methods is highly desirable.

Responsibilities

Execute the genetic engineering and characterization of CHO host and production cell lines and optimize processes to improve all stages of pipeline development.
Identify and implement advanced technologies strategically to support accelerated biological pipeline programs.
Conduct general laboratory research proficiently and independently, adapting and troubleshooting experimental designs and equipment to meet research requirements.
Apply creative thinking to solve complex problems and promote new technologies, while effectively communicating mission and ideas to diverse audiences.
Author and review technical reports; present data to the group and to leadership; read literature; contribute scientific insights to project teams.
Collaborate closely with cell line development, cell culture, analytical, purification, and bioinformatics colleagues to meet project timelines
Adhere to corporate standards for code of conduct, safety, materials handling, and good documentation practices.
Manage multiple projects across therapeutic disciplines within a dynamic and fast-paced team setting.