Senior Scientist I - Early Analytical Development, Synthetic Molecules

AbbVie•North Chicago, IL

3h•$96,500 - $183,500

About The Position

For the Senior Scientist I/II position, we are seeking a highly motivated candidate who can conceive, implement and execute novel scientific research and development, independently develop, optimize new methods and techniques to generate reliable and reproducible data in a timely manner and demonstrate broad versatile technical expertise. They will support early phase development of New Synthetic Molecules particularly newly emerging modalities such as peptides, siRNA, conjugatable payloads for antibody-drug conjugates, and small molecules, in both the preclinical- and clinical-development space and collaborate within the global Analytical R&D organization and with R&D cross-functional partners such as Pre-Clinical Safety (PCS), Process Chemistry, Process Engineering, Drug Product Development (DPD), Quality Assurance (QA), and CMC-Regulatory Affairs. This position will focus primarily on transitioning NCEs from Discovery into Development Sciences and the individual will independently serve as an Analytical Research and Development representative in a highly cross-functional team, which includes Discovery, Process Chemistry, Quantitative and Translational ADME Sciences (QTAS), Safety Pharmacology, Pre-Clinical Safety (PCS), and Molecular Profiling and Drug Delivery (MPDD). Candidates should be comfortable discussing organic chemistry topics relevant to analytical chemistry, such as stereoisomers, common functional groups, and pKa values. Experience with chromatographic analysis (such as HPLC or GC) and Mass Spectrometry is highly preferred.

Requirements

Bachelors, Masters, or Ph.D. in Chemistry (Analytical/Organic/Medicinal) or Pharmaceutical Sciences typically with minimum 10+ (BS), 8+ (MS), or 0+ (Ph.D.) years related industry experience.
Strong technical background in synthetic molecule (e.g. small molecules, synthetic RNA/DNA, synthetic peptides, etc) development with excellent analytical problem-solving skills. Capable of independently developing and troubleshooting analytical methods.
Demonstrated experience with HPLC analysis and method development preferred along with expertise and fundamental understanding of spectroscopic techniques as they relate to synthetic molecule development and small molecules.
Comfortable discussing organic chemistry topics within analytical R&D and with partner functions. Hands-on experience with synthetic organic chemistry preferred.
Self-motivated, hard-working, detail-oriented individual able to work in a fast-paced team environment.
Experience in the use of computerized data handling systems.
High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.
Practical knowledge of organic structure, functional groups, chemistry, and modern spectroscopic techniques as applied to small-molecule analytical analysis.
Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
Learns fast, grasps the "essence" and can change course quickly where indicated.
Creates a learning environment, open to suggestions and experimentation for improvement.
Embraces the ideas of others, nurtures innovation and manages innovation to

Nice To Haves

Experience with chromatographic analysis (such as HPLC or GC) and Mass Spectrometry is highly preferred.
Hands-on experience with synthetic organic chemistry preferred.

Responsibilities

Responsible for efficiently leading and supporting new synthetic modality product development, from an analytical perspective, while working with cross-functional areas to advance projects through the development pipeline.
Support new synthetic modality product development with advanced analytics to drive the pipeline and impactful research initiatives.
Utilize understanding of a range of analytical techniques to conduct research and development studies related to synthetic-molecule drug substances, impurities, and impurity profiling.
Highly autonomous and productive in performing laboratory research and/or method development, requiring only minimal direction from or interaction with supervisor.
Initiate new areas of investigation that are scientifically meaningful, reliable, and can be incorporated directly into a research or development program.
Formulate conclusions and design follow-on experiments based on multidisciplinary data.
Process, interpret, and visualize data to facilitate project team decisions.
Routinely demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
Responsible for method development, testing procedures, and implementation of analytical control strategies to help the advancement of drug discovery candidates.
Raises the bar and is never satisfied with the status quo.