Senior Scientist I, Discovery Pharmacology

Arrowhead Pharmaceuticals•Madison, WI

1d•$120,000 - $130,000

About The Position

Arrowhead Pharmaceuticals, Inc. is a commercial stage biopharmaceutical company focused on developing medicines that treat intractable diseases by silencing the genes that cause them. The company utilizes a broad portfolio of RNA chemistries and efficient modes of delivery to trigger the RNA interference (RNAi) mechanism, aiming for rapid, deep, and durable knockdown of target genes. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing to address diseases with a genetic basis, often characterized by the overproduction of disease-involved proteins. Their technologies enable the potential to address conditions in virtually any therapeutic area and pursue disease targets not addressable by small molecules and biologics. Arrowhead is a leader in bringing RNAi to diseases outside the liver and has a clinical pipeline targeting liver and lung diseases, along with promising preclinical candidates. The company is headquartered in Pasadena, CA, with R&D teams in Madison, WI & San Diego, CA, and a manufacturing facility in Verona, WI. Their employees are described as nimble, science-driven innovators collaborating to bring new therapies to patients.

Requirements

PharmD or PhD degree in immunology, cell biology, molecular toxicology, pharmaceutical sciences or pharmacology.
2+ years of pharmaceutical industry or relevant postdoctoral experience.
Track record of scientific publications in high-profile journals
Deep understanding of cell biology, immunology, cell-culture and cell-based assay development.
Experience in drug metabolism and safety
Demonstrated motivation, tenacity, innovation, creativity and resilience in problem solving
Excellent oral and written communication skills
Self-motivated team player with the ability to thrive in a fast-paced, multidisciplinary, matrixed environment

Nice To Haves

Expertise in immunology and/or molecular toxicology.
Experience at the interface of drug metabolism and safety.

Responsibilities

Design, execute and interpret in vitro, ex vivo and in vivo studies to facilitate drug discovery and development by way of understanding mechanisms of action
Develop and optimize new cell-based functional assays to achieve project goals
Support Biology and cross-functional team members in understanding various aspects of drug mechanism
Independently read and apply relevant scientific literature to projects, troubleshoot and solve problems
Present research findings to project teams and governance bodies and prepare technical reports
Present research findings externally (conferences, journal publications)
Maintain a high level of productivity in the lab and perform critical experiments