Senior Scientist I, Data Science

Sail Biomedicines•Cambridge, MA

About The Position

Join our team and drive the future of programmable eRNA TM therapeutics and In Vivo CAR-T therapies- where AI-driven biology, targeted delivery systems and next-generation immunotherapy converge to redefine what ’ s possible for patients . As a key member of the Sail Biomedicines Data Science team, the Senior Scientist I will operate at the interface of platform and program , applying data-driven approaches to champion broad platform efforts and hands-on analysis of preclinical datasets to transform the treatment landscape for autoimmune disease s , and beyond . The ideal candidate will combine strong biological insight with quantitative rigor, applying data-driven approaches to extract actionable understanding from complex preclinical and platform datasets while helping establish scalable computational foundations for future discovery efforts. In addition to supporting in vivo CAR immunology programs, this role will co ntribute to emerging capabilities in systems modeling , computational protein design, molecular modeling, and AI/ML-enabled therapeutic engineering . Partnering closely with experimental scientists, you will spearhead efforts to translate platform and program data into actionable understanding of biology, enabling rapid iteration across our therapeutic learn ing cycle.

Requirements

Ph.D. in Computational Biology, Bioinformatics, Systems Biology, Biophysics or related field
3+ years of experience analyzing multifaceted biological datasets in biotech, pharma, or academia
Firsthand experience working in CAR-T or RNA therapeutics .
Demonstrated experience ing modeling (statistical, system) to biological data .
Strong expertise in high-dimensional data analysis (e.g., RNA-seq, single-cell, in vivo studies) with the ability to transform raw data to refined downstream biological interpretations
Proficiency in Python and/or R, with strong data analysis and visualization skills and a firm grasp of modern statistics (mixed models, Bayesian methods, etc.)
Experience building reproducible and well-documented analysis workflows ( Nextflow , Snakemake )
Experience applying sound data orga nization and m etadata practices
Demonstrated ability to champion cross-functional efforts in close collaboration with experimental scientists, taking ownership and driving insights even in areas outside your core subject matter expertise

Nice To Haves

Computational design of Antibody/ VHH/ scFv /CAR proteins
Experience in immunology, cell therapy, or CAR biology , particularly in vivo systems
Experience integrating complex datasets and cross-study meta-analysis
Exposure to cloud-based or collaborative data environments
Track record of impactful scientific contributions (publications or program support)

Responsibilities

Perform in-depth analysis of preclinical and platform datasets , including immunophenotyping, functional assays, and multi-omics data to support both therapeutic programs and platform development
Integrate and interpret data across studies and contexts to generate biological insights that inform CAR activity, persistence, immune dynamics and platform-level understanding of our therapeutics
Collaborate closely with immunology and platform teams to inform experimental design and interpret results
Work resourcefully with internal / external datasets to contextualize findings and strengthen conclusions
Apply statistical and systems modeling to develop deeper understanding of product and platform attributes and performance.
Apply and promote best practices in data structuring, annotation, and metadata usage to enable reliable , scalable and reusable downstream analysis across programs and platform efforts
Develop and maintain reproducible analysis workflows , with clear documentation and version control (Git)
Contribute to a well-organized data environment by following FAIR-aligned practices in day-to-day work
Communicate findings clearly with collaborators through visualizations, presentations, and written summaries