Senior Scientist I, Analytical & Purification Sciences
About The Position
The Analytical and Purification Sciences (APS) group at AbbVie offers an exciting opportunity for a Senior Scientist within the Technology and Therapeutic Platforms organization in Discovery Research. This group provides essential technologies to support Discovery Medicinal Chemistry initiatives. The successful candidate will be responsible for executing compound purification using preparative HPLC and/or SFC, and for developing innovative solutions to complex analytical and separation challenges through the application of sophisticated instrumentation. The scientist will also serve as a lead scientist in their area of expertise on various projects, critically evaluating scientific advancements and integrating this knowledge into research programs.
Requirements
- PhD or MS in Organic Chemistry, Analytical Chemistry, or related fields with 0+years (PhD); 8+ years (MS); or 10+ years (BS) of postdoctoral and/or pharmaceutical industry experience.
- Hands-on experience with analytical and preparative scale HPLC and/or SFC.
- Ability to operate and troubleshoot a variety of analytical and preparative instrumentation hardware and software.
- Knowledge of synthetic organic chemistry and the ability to communicate effectively with medicinal chemistry teams.
- Demonstrated record of achievement in chiral/achiral purification on milligram to gram scale for a variety of programs using multiple approaches and technologies.
- Proven effective written and verbal communication skills and ability to interact with scientists and engineers.
Nice To Haves
- Experience in analytical and purification techniques for peptides.
- Experience of working in a fast-paced purification group and communicating effectively with Medicinal Chemistry teams.
- Experience in reversed-phase separations using HPLC.
- Experience in chiral separations using HPLC and SFC.
- Experience with instrument development, automation, programming, and data analytics.
Responsibilities
- Maintain a high level of productivity in the laboratory setting.
- Collaborate with medicinal chemistry teams through developing methods and providing technical guidance to solve analytical and purification problems.
- Innovate within the Analytical and Purification Sciences group to develop efficient workflows for sample prioritization and client communication.
- Execute compound purification on milligram to gram scale using preparative HPLC and/or SFC, to support small molecule drug discovery projects.
- Maintain analytical and preparative HPLC and SFC instrumentation and independently troubleshoot instrument problems.
- Proactively mentor colleagues in technical development and in establishing positive and productive working relationships.
- May supervise one or more direct reports.
- Keep abreast of current literature and industry trends to assess new approaches in high-throughput purification and analytical technologies.
- Propose and implement new initiatives/directions for the team.
- Maintain a highly productive purification workflow, establish strategies that effectively optimize available equipment and personnel, and promote efficiency and enable new paradigms in Medicinal Chemistry.
- Demonstrate a high degree of responsibility in maintaining scientific standards and safe laboratory practices.
- Keep accurate and current records of research and/or project related activities according to AbbVie policies.
Benefits
- Paid time off (vacation, holidays, sick)
- Medical/dental/vision insurance
- 401(k)
- Short-term incentive programs
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
