Senior Scientist Functional Genomics

The businesses of Merck KGaA, Darmstadt, Germany•Billerica, MA

1d•$96,600 - $159,600•Onsite

About The Position

EMD Serono is hiring a functional genomics specialist Scientist/Senior Scientist to join the Discovery Biology group within Research Unit Neuroscience & Immunology (RU-N&I) at our state-of-the-art research facility in Billerica, MA. We are building a functional genomics group to collaborate with an international team of scientists, contributing to the discovery of drugs for neurodegenerative/neuroinflammatory and autoimmune diseases. Working with disease biology experts, the functional genomics team will use gene editing methods to identify and validate new targets as well as to generate cell models. Our cross-functional group will explore novel biology and deliver genetic evidence to advance the Neuroscience & Immunology pipeline.

Requirements

PhD in a life science field, (e.g., Biology, Biotechnology, Genetics, etc.) OR Masters Degree in a life science field (e.g., Biology, Biotechnology, Genetics, etc.) with 6+ years of lab academic or industry experience
2+ years’ experience with complex cell culture systems and primary cells or iPSCs
2+ years using and designing gene editing tools for high throughput applications and hands-on execution of pooled or arrayed CRISPR or siRNA screens

Nice To Haves

Background in immunology or neuroscience, with experience working with in vitro cell systems e.g. iPSC differentiation or immune cell isolation
Experience analyzing and disseminating data to support key decision making
Broad experience in molecular and cellular biology, including Multicolored FACS and analysis, High-content imaging and analysis, NGS library preparation, Single cell omics data generation and principals of analysis, Lentiviral vector design and experience packaging and using lentivirus for gene expression, Reporter construct design
Familiarity with documentation practices in a pharmaceutical or biotechnology discovery setting
Strong verbal and written communication skills and practiced at communicating research findings to cross-disciplinary teams
Curious, highly collaborative scientist with enthusiasm for exploring novel biology

Responsibilities

Independently plan, execute and lead in vitro studies using complex cell systems
Leverage your skills in advanced CRISPR techniques and cell biology to identify and validate new targets and advance our pipeline
Use pooled, arrayed, and single cell functional genomics methods to interrogate disease biology at scale
Work with a range of NGS, imaging, and FACS-based readouts to explore the roles of candidate genes in neurologic and immunologic disease
Work with disease biology experts to develop cellular models and assays
Record data accurately in an Electronic Laboratory Notebook and maintain records per company policy and legal requirements
Prepare data reports and present to lab heads, project teams, and at external meetings
Provide technical support to colleagues in own area of expertise when necessary
Work closely with members in RU-N&I to support departmental goals