Senior Scientist, Formulation and DP Development

Sutro Biopharma•South San Francisco, CA

33d•Onsite

About The Position

Sutro Biopharma, Inc. is looking for a technical leader who will report to the Executive Director of Formulation and DP Development. You will be developing new compositions for biologic / conjugated molecules and creating robust DP manufacturing processes to advance Sutro's pipeline and enhance our internal and collaborative product development initiatives in a fast-paced environment.

Requirements

BS/MS (12+ years) or PhD (7+ years) of experience in scientific discipline (Pharmaceutical Sciences, Chemistry, Chemical Engineering, Biomedical Engineering, or related discipline) and demonstrated scientific creativity and contributions.
Solid technical skills and experience in pre-formulation screening studies, biophysical/biochemical characterization of proteins, analytical method development and protein/antibody/ADC product development is essential.
Practical experience with design and execution of in-use stability studies for biologics and compatibility with administration components.
Demonstrated ability to design experiments and routinely generate new ideas and original research.
High level of scientific initiative and independence.
Highly autonomous requiring minimal supervision from manager.
Working knowledge of cGMP and relevant drug product development guidelines and regulations.
Excellent oral and written communication skills.
Being detailed oriented.

Nice To Haves

Analytical instrumentation such as chromatographic (HPLC, UPLC, column chromatography), visible and subvisible particle analysis, capillary electrophoresis and/or biophysical techniques (UV-vis, MALS/DLS, DSC, CD, FTIR, AUC, Fluorescence spectroscopy) for protein characterization are highly desirable.

Responsibilities

Participate in formulation and DP development for phase appropriate liquid and lyophilized formulations for intermediates, drug substance and drug products.
Participate in activities in technology transfer to CMO’s.
Design, execute, document formulation, stability and in-use/compatibility studies to support the final formulation, clinical administration and manufacturing processes.
Utilize/implement fit-for-purpose analytical methods for biophysical characterization, formulation and process development and stability testing.
Communicate experimental data both verbally at group, department and cross functional meetings and through written documents and reports that may be included in regulatory filings.
Cooperate effectively with cross functional teams, such as up and down stream process development, manufacturing and quality.
Quickly adapt to changes in project direction.
Work on multiple projects between departments in a fast-paced environment.