Senior Scientist - Early BioProcess Development

Pfizer • Pearl River, NY

1d • Onsite

About The Position

We are seeking a highly motivated Senior Scientist in Conjugation Process Development within Vaccines Early BioProcess Development. The Senior Scientist will serve as a strong technical contributor and project leader focused on hands-on process development, experimental execution, data interpretation, and cross-functional collaboration in the field of conjugate vaccines. You will join a larger team of scientists focused on developing conjugation processes for carbohydrate-based and other modality-based conjugate vaccines. Key responsibilities include developing and optimizing conjugation methods, analyzing glycoconjugates, supporting purification process development, and contributing to scale-up activities. The individual will be expected to independently plan and execute experiments, solve technical problems, mentor junior colleagues, and provide day-to-day scientific guidance while partnering with senior leaders to advance vaccine candidates through early development.

Requirements

• Applicant must have a bachelor's degree in science with at least 9+ years of experience; OR a master's degree in Organic Chemistry/Carbohydrate Chemistry with at least 7+ years of experience; OR a PhD in Organic Chemistry/Carbohydrate Chemistry with 0+ years of experience.
• Hands-on experiences with carbohydrate protein conjugation, purification processes and analysis
• Understanding of the design, planning, and execution of conjugation and purification activities including the operation and maintenance of relevant instruments, resolution of technical problems related to instruments, and execution of analytical/biophysical characterization methods.
• Experience with a variety of state-of-the-art analytical techniques including NMR, Mass Spectrometry etc. and other analytical techniques.
• Independently analyze and provide conclusions regarding experimental data generated.
• Proficiency with personal computers including word processing, spreadsheets, PowerPoint, and relevant scientific software
• Excellent organizational, interpersonal, and communication skills (both written and verbal) to effectively influence and collaborate in a fast-paced, multi-disciplinary team environment.
• Ability to drive projects to completion and meet deadlines.
• Strong organizational and project management skills.
• Permanent work authorization in the United States.

Responsibilities

• Provide day-to-day scientific leadership for assigned conjugation process development activities, including experimental planning, troubleshooting, data review, and coordination of laboratory priorities.
• Mentor and train junior scientists, associates, and new team members by providing technical guidance, reviewing experimental designs, supporting skill development, and modeling strong scientific rigor and documentation practices.
• Demonstrate leadership through influence by helping align team members around project goals, communicating technical priorities clearly, and escalating risks or resource needs in a timely manner.
• Design, develop, optimize, and scale up conjugation processes for glycoconjugate vaccine candidates, including evaluation of conjugation chemistries, activation strategies, reaction conditions, and purification approaches.
• Plan and execute scientifically rigorous experiments to support process understanding, robustness, scalability, and manufacturability of conjugate vaccine candidates.
• Analyze experimental data, interpret results, draw scientifically sound conclusions, and use findings to guide process development decisions and next-step recommendations.
• Present project updates, technical strategies, risks, and recommendations to internal teams, leadership forums, and cross-functional stakeholders within EBPD and Vaccines.
• Support technology transfer of developed processes to internal and external clinical manufacturing sites by preparing technical information, contributing to process descriptions, and providing troubleshooting support as needed.
• Keep abreast of scientific/technological development by participating in scientific meetings/seminars and through regular scientific review.
• Utilize new technologies and establish those technologies to improve conjugation process.
• Continuously evaluate each process and technique to determine if it is robust, appropriate, and scalable. If an operation has shortcomings or can be improved, uses expertise and imagination to suggest improvements.
• High-quality documentation of experiments in electronic lab notebooks, author technical reports as needed.

Benefits

• 401(k) plan with Pfizer Matching Contributions
• Additional Pfizer Retirement Savings Contribution
• Paid vacation
• Holiday and personal days
• Paid caregiver/parental and medical leave
• Health benefits to include medical, prescription drug, dental and vision coverage
• Relocation assistance may be available

What This Job Offers

• Job Type: Full-time
• Career Level: Senior