Senior Scientist, Discovery Pharmacology

Altos Labs • San Francisco, CA

9h • Onsite

About The Position

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. At Altos, your work will be at the heart of a mission to transform medicine by reversing disease and restoring cell health. You will contribute to the development of a new generation of drugs rooted in an advanced understanding of cellular rejuvenation and resilience. As a Sr Scientist of Discovery Pharmacology team, your primary focus will be supporting the in vitro pharmacology needs of the Drug Discovery and Development (3DS) division of Altos. This is a laboratory research scientist position focused on the development and execution of cell-based and biochemical assays, and complex in vitro models. Your work will contribute to our drug discovery campaigns across a diverse portfolio of drug discovery and development stage projects. Your expertise will be instrumental in driving our mission and making a significant impact in aging/rejuvenation biology and drug discovery.

Requirements

• A Ph.D. (Pharmacology, Bio, etc.) plus at least 6 years of post-PhD experience AND 3+ years industry experience in drug discovery and development.
• Ability to design your own experiments and get solid, repeatable results.
• Major experience with cellular and biochemical assays and complex in vitro models.
• Proficiency with lab automation and high-throughput techniques (Bravo, Echo, I.DOT, and tech like MSD, HTRF, AlphaLISA).
• Good communication skills, fast, organized, and able to handle a lot.
• Experience working with outside labs (CROs).

Nice To Haves

• Experience with high-content imaging in high-throughput settings (96- and 384-wells).
• Experience with different drug types (small molecules, nucleic acids, gene therapies).
• Knowledge of aging/rejuvenation biology.
• Screening experience with various modalities (small molecules, siRNA, ASO).
• Familiarity with microfluidics assays.

Responsibilities

• Investigate and validate drug targets, define mechanisms of action (MoA) through robust pharmacology strategies.
• Design, automate, and troubleshoot all kinds of assays.
• Analyze data and present it to help make project decisions.
• Keep great records in the electronic lab notebook (ELN), ensure reproducibility and data integrity.
• Work with people across different teams, including the Product Development crew.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree
• Number of Employees: 11-50 employees