Senior Scientist, Computational Biology

Eikon Therapeutics•Millbrae, CA

About The Position

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets. Position We seek a Senior Scientist in Computational Biology to drive diverse early drug discovery efforts across Eikon’s target portfolio. In this key role, the successful applicant will use their rigorous analytical skills in close collaboration with diverse discovery scientists to conceive and evaluate complex, progress-enabling experiments across our target portfolio. This person will also help shape how Eikon evaluates and adopts novel experimental systems and will partner with colleagues developing quantitative models to ensure that emerging computational methods remain grounded in sound biological reasoning.

Requirements

Postdoc Fellowship plus 2 years of relevant experience or PhD in bioinformatics, computational biology, or a quantitative field with deep expertise in statistics or method development, plus 5 years of relevant industry experience.
Hands-on experience developing and applying methods for high-dimensional, multi-modal datasets, including experience designing, evaluating, and integrating high-throughput experiments.
Ability to independently define analytical approaches for novel technologies, develop effective solutions, and validate results with minimal oversight.
Proven experience analyzing complex genomics datasets across one or more technical modalities, such as bulk, single-cell, or spatial transcriptomics, pooled or arrayed CRISPR screens, MAVEs or other multiplexed reporter assays, high content imaging data, Perturb-seq, or other relevant technologies
Experience working with large consortia and public datasets such as UK Biobank, TCGA, GTEx, ENCODE, gnomAD, and Human Cell Atlas.
Expertise using one or more high level programming language (e.g., R, Python, or similar) to solve biological problems; well versed in modern coding and computing best practices such as cloud deployment, version control, containerization, etc.
Demonstrated record of impactful research, evidenced by publications in peer-reviewed journals.
Excellent interpersonal, written, and verbal communication skills.

Nice To Haves

Additional weight will be given to qualified applicants with experience partnering with computational/algorithms teams on statistical or machine learning model development and/or methodological development.

Responsibilities

Drive the development and adoption of novel experimental systems and techniques relevant to Eikon’s target portfolio, collaborating closely with experimental and computational teams across programs
Develop and apply analytical approaches, statistical methods, and proof-of-concept tools to support new experimental strategies
Analyze multimodal data to evaluate experimental systems, identify enabling insights, and define the limits of interpretation for biological applications
Apply statistical, biological, and experimental expertise to evaluate complex experiments.
Distill information from diverse sources to reach relevant and testable biological conclusions

Benefits

bonus and equity compensation
401k plan with company matching
Medical (premiums covered by Eikon at 95%)
dental and vision insurance (premiums covered by Eikon at 100%)
Mental health and wellness benefits
Weeklong summer and winter holiday shutdowns
Generous paid time off and holiday policies
Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
Enhanced parental leave benefit
Daily subsidized lunch program when on-site