Senior Scientist, Cell Therapy Research, Molecular Immunobiology and Discovery Team (In vivo CAR-T)

Bristol Myers Squibb • Seattle, WA

3d • Onsite

About The Position

The Cell Therapy Molecular Immunobiology and Discovery team is seeking a highly motivated, dynamic and self-driven individual to help us build out our molecular engineering and gene delivery capabilities. Effective delivery of optimal cargo will be the foundation of our next generation of cell therapies. Innovations in this space will drive the future of our cellular therapeutic pipeline at BMS, enabling us to bring best-in-class engineered drugs to our patients. This role will primarily focus on developing and validating technologies to efficiently generate potent CAR-T cells. The ideal candidate is an experienced molecular biologist and lentivirologist with a strong background in immunology. They will have a conceptual and practical understanding of CAR-T cell biology, and knowledge of key challenges related to lentiviral vector transgene delivery in vitro and in vivo. This role will provide a challenging but rewarding opportunity for career development and is ideal for a scientist with an innovative mindset. Previous experience in cellular therapy, industry or academic, is preferred.

Requirements

• Bachelor’s Degree 7+ years of academic/industry experience Or Master’s Degree 5+ years of academic/industry experience Or Ph.D. or equivalent advanced degree in the Life Sciences 2+ years of academic/industry experience
• Expertise with lentiviral vectors and their use in engineering T-cells
• Technical expertise with lentiviral vector related functional assays; including various means of titration, multi-parameter flow cytometry, and assessment of protein expression.
• Familiarity with in vitro technologies typically employed to assess T cell functionality including but not limited to MSD, IncuCyte-based cytolytic function assays, T cell activation assays, T cell proliferation analysis, imaging.
• Self-motivated and focused with project management-oriented thinking including timelining of key deliverables and dependencies
• Strong organizational skills to ensure thorough and timely documentation of experiments and preparation of data for clear presentation to program stakeholders and decision-makers
• Detail-oriented with a discerning eye on data interpretation, presentation, and assay trouble-shooting
• Strong interpersonal skills and willingness to collaborate within cross-functional teams; skilled at listening to and coordinating with colleagues in a matrixed environment
• Ability to multitask, independently organize time, and plan specifics of work.
• Excellent communication and facilitation skills demonstrated in a team environment.
• Willingness to improvise, be pragmatic, and work in a very fast-paced environment with changing priorities
• Strategic supervisory experience with a passion to help guide direct reports to progress in their careers

Nice To Haves

• Previous experience in cellular therapy, industry or academic, is preferred.
• Conceptual and practical understanding of CAR-T cell biology, and knowledge of key challenges related to lentiviral vector transgene delivery in vitro and in vivo.

Responsibilities

• Plan and implement critical studies required for platform building and hypothesis-driven research for building the next generation lentiviral vectors
• Apply extensive knowledge of lentiviral vector biology to develop and execute creative strategies for increasing yield, throughput, and the robust streamlined assessment of novel lentiviral vector platforms
• Interface with immunologists to interpret and enable science-driven decision making related to aspects of T-cell activation pathways, antigen-specific differentiation, and CAR-T cell phenotype to assess different lentiviral vector cargo and delivery strategies
• Strong ability to interpret and synthesize information from complex datasets, both published and internal within BMS
• Provide scientific and technical insights on cross-functional assignments related to the evaluation of lentiviral vectors
• Provide recommendations on department-level strategic decisions
• Act as a functional advisor to team members, especially to more junior colleagues
• Design experiments, organize and analyze results and communicate progress to the group to enable efficient Go/No Go decisions.
• Work with other team members and team leaders to enable adoption of novel methods and designs in ongoing programs.

Benefits

• wellbeing support
• retirement and financial protection benefits
• insurance offerings (medical, dental, vision, life and disability)
• Flexible Time Off (FTO)
• 11 paid company holidays each year
• 160 hours of paid vacation annually for new hires
• 3 optional holidays
• paid sick leave
• up to two paid volunteer days per year
• summer hours flexibility
• leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs
• annual Global Shutdown between Christmas Day and New Year's Day

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree