Senior Scientist, Cell Pharmacology

Xilio Therapeutics•Waltham, MA

1d•Onsite

About The Position

Xilio Therapeutics is a development-stage biotechnology company advancing next-generation cancer immunotherapies designed to improve patient outcomes by unleashing the power of the immune system selectively at the site of the tumor. The company’s tumor-selective immunotherapies are based on its proprietary technology, which maximizes the potency of proven immuno-oncology therapies and restricts their activity to the tumor to minimize peripheral side effects. The broad applicability of these therapies across cancer types means that all patients could benefit from these potentially curative medicines. Xilio was founded in 2016 and closed a $100.5M Series B financing from blue chip venture investors in February 2020. Xilio is headquartered in Waltham, MA. SUMMARY: Xilio Therapeutics is seeking an Associate Scientist to join our In Vivo Pharmacology group. This individual will be responsible for conducting preclinical studies in animal tumor models (efficacy, PK/PD and MOA studies) to characterize immuno-oncology focused protein therapeutics. They will also perform downstream in vitro assays.

Requirements

M.S. or B.S. in the field of immuno-oncology, or other related fields with 3-5+ years (B.S.) or 1-2+ years (M.S.) experience working in a CRO, biotechnology or pharmaceutical company
Technical experience with development, qualification, and execution of studies in subcutaneous syngeneic tumor models (orthotopic tumor models is a plus), as well as PDX and/or humanized tumor models
Experience with cell culture of primary cells and cell lines
Experience with IACUC documentation
Strong communication and teamwork skills are essential as this individual is expected to operate in a fast-pace multi-disciplinary environment

Nice To Haves

Experience with pharmacokinetic analyses would be preferred
Experience with ELISA and/or FACS analyses of in vivo models is desirable

Responsibilities

Design and execute studies to investigate the efficacy, safety and PK/PD of protein therapeutics including analysis of data with the appropriate statistical tools
Perform routine animal handling procedures and injections (SC, IP, IV, PO, IT) in mice, monitor animal health, measurements, and tissue collection for ex vivo analysis
Support the implementation and validation of new animal models
Meet all guidelines set by Xilio’s IACUC
Perform ex vivo analysis including ELISA, ELISpot, MSD, flow cytometry
Ensure data is captured in appropriate databases and electronic laboratory notebooks
Regular participation and presentation at Project Team and departmental meetings.
Collaborate with other members of the In Vivo Pharmacology team