Senior Scientist, Biology-Discovery

MSD • Upper Gwynedd Township, PA

7d • $117,000 - $184,200 • Onsite

About The Position

We’re seeking an experienced Senior Scientist to join the Infectious Disease and Vaccines department at our research site in West Point, PA. The candidate will have a primary role on a team responsible for the discovery and development of novel antiviral treatments, with a particular focus on HIV. The candidate will independently design and execute hands-on experiments to interrogate fundamental virus biology, virus-host interactions, and immunological responses using various biochemical and cell-based assays and in vivo disease models. The candidate should have a strong background in virology, translational animal models, immunoassay and genomic technologies, cell biology, animal pharmacology, and general knowledge of infectious disease drug development and T cell biology. We value creative-thinking, teamwork, and independent analytical problem solving. If you are a highly motivated team player with a strong desire to impact basic research and translational medicine, we invite you to consider joining our team.

Requirements

• BS/BA degree in Biology or Biomedical Sciences with a minimum 7 years of experience in industry and/or academia, or a MS degree in Biology or Biomedical Sciences with 4 years of experience in industry and or academia, or PhD with >1-year postdoctoral experience.
• Highly skilled in virology with expertise in a range of virological, molecular and cellular techniques, including in vitro and in vivo disease models.
• Experience with rodent handling and small-animal procedures, including injections (IP, SQ, IV, PO), blood sampling (IV, RO), and tissue collection and analysis.
• Proficiency in HIV biology, including latency, and demonstrated rigorous productive research in investigative viral replication, virus-host interactions, innate and adaptive immunity, and HIV pathogenesis.
• Proven track record in immunological and molecular techniques, including cell culture and T-cell purifications, virus production, ELISA, flow cytometry, PCR, and has experience with animal pharmacology.
• Knowledgeable in drug discovery and translational research.
• Good communication (verbal & writing) skills with a track record of publications.
• Solid computer skills, independent experimental design and execution, analytical problem-solving capabilities, and ability to work collaboratively in a multi-disciplinary team environment.
• Keen awareness of emerging biology and new technologies.

Nice To Haves

• Multi-parameter Flow cytometry and ICS.
• Experience with instruments including BD Symphony, LSR II, and FACSARIA and Sony SH800 desirable.
• Knowledge of biomarker discovery and assay development as it relates to infectious diseases and immune responses, particularly 10X genomics or other immuno-profiling platform experience.
• In vitro and ex-vivo probing of tissues for host-pathogen responses using biochemical methods, cell-based assays, and in vivo disease models, particularly for infectious disease.

Responsibilities

• Independently design and execute hands-on experiments to interrogate fundamental virus biology, virus-host interactions, and immunological responses using various biochemical and cell-based assays and in vivo disease models.
• Contribute to the discovery and development of novel antiviral treatments, with a particular focus on HIV.

Benefits

• medical, dental, vision healthcare and other insurance benefits (for employee and family)
• retirement benefits, including 401(k)
• paid holidays
• vacation
• compassionate and sick days
• annual bonus
• long-term incentive

What This Job Offers

• Job Type: Full-time
• Career Level: Senior