Senior Scientist, Biologics Purification II

AbbVie•North Chicago, IL

About The Position

Join AbbVie’s Biologics Discovery Sciences group and make a tangible impact in advancing innovative biologic therapies. As a scientist specializing in Biologics Purification, you will play a pivotal role in driving drug discovery, collaborating within a dynamic team dedicated to supporting transformative science that improves patient lives worldwide. Your expertise will help deliver high-purity bispecific antibody-based biologic candidates with suitable purity/characteristics to support the advancement of vital in vitro (i.e. drug-like property assays, binding, cell-based assays, etc.) and in vivo studies (i.e. efficacy, non-GLP NHP PK, DRF, etc.).

Requirements

BS, MS, or PhD in Bioinformatics, Biophysics, Chemical Engineering, or related field with typically 12+ years (BS), 10+ years (MS), or 4+ years (PhD) of experience
Deep proficiency in bioprocessing, column chromatography, and biotherapeutics manufacturing
Experience operating high throughput automated liquid handling systems for chromatography applications (i.e. plate-based screening, robocolumns)
Demonstrated success designing and executing DOE studies with successful application to protein production scale-up
Experience with chromatography instrumentation and software (i.e. Unicorn) is required
Exceptional analytical, communication, and presentation skills
Collaborative spirit and dedication to scientific excellence

Nice To Haves

Experience developing bioinformatics tools and API’s for real-time data acquisition, extraction, and storage in LIMS environments is preferred.
Familiarity with programming languages (i.e. Python) and AI/ML tools is a plus
Strong understanding of molecular and post-translational attributes of biologics

Responsibilities

Lead small-scale (<1L) purification of bispecific antibody biologics to support critical research assays and studies
Design and execute advanced chromatography techniques and robust bioprocess development strategies to address production impurities and liabilities to deliver high quality biologics to therapeutic areas
Apply Design of Experiments (DOE) with high throughput automation to optimize chromatography conditions for enhanced separation and resolution of complex protein mixtures
Leverage AI and programming expertise to design and build data capture workflows and data warehousing infrastructure that supports machine learning development.
Collaborate with multidisciplinary teams, translating molecular insights into functional results
Stay current with emerging scientific literature to foster innovation and continuous improvement
Present findings clearly to diverse audiences and document results with rigor