Senior Scientist, Bioanalytical Science

Seaport Therapeutics•Boston, MA

1d•$133,000 - $157,000•Onsite

About The Position

Seaport Therapeutics is a clinical-stage therapeutics company focused on developing novel neuropsychiatric medicines for unmet patient needs. They utilize a proprietary GlyphTM technology platform to create first and best-in-class medicines with improved oral bioavailability, reduced metabolism, and fewer side effects. The company is seeking an experienced scientist to play a key role in advancing preclinical discovery of its lipid prodrug platform. This role involves contributing to a bioanalytical program to understand the functionality of the platform and aid in selecting development candidates. The scientist may also expand into DMPK and ADME functions. The ideal candidate will thrive in a collaborative and innovative environment, embodying values of patient service, ownership, entrepreneurial spirit, technical excellence, teamwork, and continuous improvement. This is an in-office position located in Boston's Seaport area, requiring a 5-day-a-week presence, and will report to the Associate Director, Bioanalytical Sciences.

Requirements

MS/PhD degree in analytical chemistry, bioanalytical chemistry, pharmaceutical analysis with 3+ years for PhD, or 8+ years for MS.
Track record of supporting the development and validation of bioanalytical LC-MS/MS methods designed at standards ranging from “fit-for-purpose” through GLP.
Hands-on familiarity running and maintaining industry-standard mass spectrometry instrumentation
Understanding of FDA and global regulatory requirements of study types assigned, as well as Testing Facility SOPs and Good Laboratory Practices (GLPs), as appropriate.
Highly motivated and results driven individual with a passion for working in a fast-paced and evolving organization
Experience with CROs and managing outsourced studies critical
Outstanding communication, interpersonal, and partnering skills
Excellent cross-disciplinary skills in communicating scientific ideas to non-scientist stakeholders to foster collaboration and deliverable-based teamwork
Ability to adjust rapidly to changing scientific priorities and technologies

Nice To Haves

Analysis of prodrugs and associated species highly desirable
Startup experience is highly valued.

Responsibilities

Support the development and optimization of bioanalytical methods (e.g. LC/MS) to evaluate concentration of API, metabolites, and related species across multiple small and large animal species
Manage execution of method development and sample analysis across multiple external CROs and collaborators
Assist in design and selection of methods of sample extraction and analysis across a range of matrices including lymph, plasma, and solid tissues
Perform pharmacokinetic analysis of data, communicate results, provide scientific interpretations and recommendations to cross-functional project teams and leadership
Contribute to the development or application of relevant pharmacokinetic models to add fundamental understanding where appropriate
Manage day-to-day research activities with increasing independence while ensuring alignment with departmental and company priorities
Coordinating bioanalytical laboratory operations including maintenance and sourcing of laboratory equipment, interfacing with lab safety or operations teams, and supply/inventory management.
Foster a scientific culture of collaboration, innovation, rigor, and transparency
Actively participate in team meetings, and contribute to reports and patent applications