Senior Scientist, AI Computational Structural Biology

Bristol Myers Squibb • San Diego, CA

9d • $141,770 - $179,601 • Hybrid

About The Position

This is a unique opportunity to shape the next generation of AI-driven drug discovery at BMS, with direct impact on our induced proximity and targeted protein degradation programs. We are seeking a collaborative and highly innovative computational biologist with a strong background in AI co-folding modeling and deep understanding of protein structures to join our Predictive Structure and Function team. They will work alongside scientists in Protein Homeostasis, Computational Sciences, Oncology and other teams in the Informatics and Predictive Sciences (IPS) department to discover novel target opportunities leveraging protein-protein interactions and apply learnings to other small and large molecule modalities.

Requirements

• Bachelor's Degree 7+ years of academic / industry experience Or Master's Degree 5+ years of academic / industry experience Or PhD 2+ years of academic / industry experience
• AI/ML & Deep Learning: Proven experience developing and deploying AI/ML models in biological or biochemical contexts, with proficiency in deep learning architectures for structural data (GNNs, equivariant neural networks, transformers, diffusion, flow matching) using Python and relevant libraries (PyTorch, JAX, RDKit, ESM/fair-esm, Biopython, etc.).
• Structural Biology and Co-folding: Deep expertise in protein-protein interactions, protein folding, and biomolecular complex formation, with hands-on experience in structure prediction and co-folding frameworks (e.g. AlphaFold2, AlphaFold-Multimer, RoseTtaFold2, Boltz, Chai-1, NeuraPlexer, or equivalent).
• Strong problem-solving mindset with the ability to design novel computational approaches for challenging biological questions.
• Experience contributing to or leading collaborative research projects with academic and/or industry partners and ability to translate scientific findings into actionable drug discovery insights.
• Self-motivated with strong organizational skills and the ability to manage multiple projects simultaneously.
• Demonstrated ability to presenting complex methods and results to scientific audiences and author high-quality scientific reports and publications to publishable standard.

Nice To Haves

• Ph.D. in Computational Biology, Bioinformatics, Structural Biology, Computer Science, Chemistry, or a closely related field, with a strong focus on AI/ML applications in drug discovery with 2+ years of post-doctoral experience in developing AI/ML approaches in university, pharma, or biotech settings, focusing on drug discovery.
• Multi-Omics Data Integration: Ability to integrate and analyze multimodal datasets—including structural, genomic, and proteomic data—from both public and proprietary sources, with experience developing algorithms to interpret genomics and proteomics data.
• Chemoproteomics & induced proximity: Familiarity with chemoproteomics data for druggability and ligandability assessment is preferred. Experience with induced proximity modalities (for example, PROTACs, molecular glues, and bifunctional molecules) is appreciated but not required.

Responsibilities

• Develop AI/ML models to predict structural biomolecular interactions for novel modalities leveraging protein-protein interactions.
• Design innovative AI/ML approaches to predict protein cooperativity, affinity & other biological properties based on structures.
• Develop co-folding models that incorporate structural and non-structural priors using combinations of public and proprietary BMS data.
• Develop AI/ML models that leverage chemoproteomics data contributing to the generation of novel druggability hypotheses for hard-to-drug targets.
• Author scientific reports, and present methods, results, and conclusions to publishable standard.
• Contribute to the planning and execution of collaborative projects with leading academic and commercial research groups worldwide.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off
• US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
• All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior