Senior/Research Associate

JLSa2 Therapeutics • South San Francisco, CA

2d

About The Position

We are seeking a highly motivated and skilled Senior/Research Associate to join our Analytical Developability team. The successful candidate will play a critical role in evaluating the developability of antibody-peptide conjugate (APCs) candidates, performing characterization, stability and developability assays to ensure the selection of high-quality drug candidates.

Requirements

• BS or MS in (Bio)chemistry, Biophysics, Biotechnology, or related field.
• 3 to 8+ years of industry experience in a biologics drug development research environment.
• Specific experience and familiarity with upstream and downstream biologics workflows and analytics.
• Hands-on experience with characterization of antibodies and antibody drug conjugates, including familiarity with upstream and downstream workflows, particularly purification and characterization.
• Understanding of antibody drug conjugate analytics.
• Communication skills.
• Strong understanding of antibody structure and function.
• Proven ability to troubleshoot and optimize analytical assays.
• Proactive self-starter with the ability to thrive in a fast-paced, collaborative startup environment.

Responsibilities

• Execute biophysical assays to assess antibody molecular properties for stability, solubility, and aggregation profiles (e.g., DLS, DSF, HPLC-SEC, SEC-MALS, LC-MS, UV-vis, iCIEF, CE-SDS).
• Meticulously collect, analyze, and document experimental data in an electronic lab notebook (ELN). Present findings to cross-functional teams.
• Independently troubleshoot assay performance and improve protocols for enhanced robustness and throughput. Proactively seek solutions to scientific problems.
• Work closely with Production, Conjugation, Development, Biology and leadership teams to advance molecules from screening to development and nomination.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Associate degree