Temp Senior Research Associate/Sr Scientist, Formulation and Delivery Sciences
About The Position
Ionis Pharmaceuticals, Inc. is seeking an energetic and detail-oriented Sr. Research Associate or Sr. Scientist to support its new gene editing franchise. This is an onsite laboratory-based role focused on nanoparticle formulations R&D for the intracellular delivery of RNA. The successful candidate will synthesize research scale RNA-loaded lipid nanoparticles, perform physical-chemical characterizations, and assist with biological testing in rodents and/or cell culture. Ionis has been a pioneer in RNA-targeted medicines for over three decades, with multiple marketed medicines and a leading pipeline in neurology, cardiology, and other areas of high patient need. The company fosters a challenging, motivating, and rewarding environment that drives innovation and scientific excellence, with a commitment to diversity and employee growth.
Requirements
- BS in life sciences, pharmaceutical sciences, chemical engineering, or related discipline with at least 5 yrs of relevant academic/industry laboratory experience (for Sr. RA level)
- PhD in life sciences, pharmaceutical sciences, chemical engineering, or related discipline with at least 2 years of relevant academic/industry laboratory experience (for Sr. Scientist role).
- Must have prior expertise in accurately synthesizing numerous bench-scale RNA-containing LNP batches using microfluidic mixing technologies and bench-scale purification.
- Must have prior experience performing nanoparticle characterization using Ribogreen, DLS, Zeta potential, etc.
- Ability to learn and perform routine rodent procedures (eg., tail vein injection and necropsy)
- A team player who can work both independently and with cross-functional teams in a fast-paced, entrepreneurial environment
- Good organizational and written/verbal communication skills
Nice To Haves
- Experience with analysis of lipids/RNAs via HPLC is a big plus.
Responsibilities
- Meticulous hands-on laboratory work synthesizing and documenting a variety of RNA-loaded lipid nanoparticles using microfluidic mixing, dialysis, filtration, centrifugation, SEC, etc.
- Perform particle analysis via Ribogreen, DLS, zeta potential, pKa determination, etc and potentially analyze lipids and RNA via HPLC.
- Assist with routine rodent procedures to dose formulations and assess safety/activity.
- Thoroughly document results in electronic lab notebooks and assist with analysis of data.
- Assist in maintaining general laboratory organization and supplies.
Benefits
- challenging, motivating and rewarding environment
- fosters innovation and scientific excellence
- develop and expand your career
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What This Job Offers
Job Type
Full-time
Career Level
Senior
