Temp Senior Research Associate/Sr Scientist, Formulation and Delivery Sciences

Ionis•Carlsbad, CA

46d•Onsite

About The Position

Ionis Pharmaceuticals, Inc. is seeking an energetic and detail-oriented Sr. Research Associate or Sr. Scientist to support its new gene editing franchise. This is an onsite laboratory-based role focused on nanoparticle formulations R&D for the intracellular delivery of RNA. The successful candidate will be responsible for synthesizing research scale RNA-loaded lipid nanoparticles, performing physical-chemical characterizations, and assisting with biological testing in rodents and/or cell culture. Ionis, headquartered in Carlsbad, California, has been a pioneer in RNA-targeted medicines for over three decades, with multiple marketed medicines and a leading pipeline in neurology and cardiology. The company fosters a challenging, motivating, and rewarding environment that drives innovation and scientific excellence, with a commitment to diversity and employee growth.

Requirements

BS in life sciences, pharmaceutical sciences, chemical engineering, or related discipline with at least 5 yrs of relevant academic/industry laboratory experience (for Sr. RA level)
PhD in life sciences, pharmaceutical sciences, chemical engineering, or related discipline with at least 2 years of relevant academic/industry laboratory experience (for Sr. Scientist role).
Must have prior expertise in accurately synthesizing numerous bench-scale RNA-containing LNP batches using microfluidic mixing technologies and bench-scale purification.
Must have prior experience performing nanoparticle characterization using Ribogreen, DLS, Zeta potential, etc.
Ability to learn and perform routine rodent procedures (eg., tail vein injection and necropsy)
A team player who can work both independently and with cross-functional teams in a fast-paced, entrepreneurial environment
Good organizational and written/verbal communication skills

Nice To Haves

Experience with analysis of lipids/RNAs via HPLC is a big plus.

Responsibilities

Meticulous hands-on laboratory work synthesizing and documenting a variety of RNA-loaded lipid nanoparticles using microfluidic mixing, dialysis, filtration, centrifugation, SEC, etc.
Perform particle analysis via Ribogreen, DLS, zeta potential, pKa determination, etc and potentially analyze lipids and RNA via HPLC.
Assist with routine rodent procedures to dose formulations and assess safety/activity.
Thoroughly document results in electronic lab notebooks and assist with analysis of data.
Assist in maintaining general laboratory organization and supplies.