Senior Research Associate / Scientist, Proteomics Sample Prep
About The Position
Glyphic Biotechnologies is developing a massively parallel, single-molecule proteome sequencing platform to transform life science discovery. We are seeking a hands-on, detail-oriented Senior Research Associate / Scientist I to join our proteomics team and help scale our sample processing capacity. The role involves day-to-day execution of tissue and cell sample preparation and mass spec operation. Reporting to the principal proteomics scientist, the position is primarily bench-based, requiring close adherence to established SOPs, preparation and running of high volumes of samples, and assisting with the calibration and maintenance of the Astral mass spec. This role offers hands-on training on the Orbitrap Astral Zoom + Vanquish Neo platform and growing ownership of the workflow as automated systems are implemented. This is a full-time, exempt, in-person position located in Berkeley, CA.
Requirements
- Industry or Academic experience relevant to the role and a degree in Proteomics, Chemical Biology, Biochemistry, Analytical Chemistry, or a related field
- BS/MS with 2+/0+ years (Senior Research Associate) or BS/MS with 4+/2+ years (Scientist I)
- Hands-on experience with LC–MS/MS–based proteomics
- Experience processing precious, complex clinical samples to include tissue dissection and cell pellet handling
- Demonstrated experience in sample preparation, protein extraction, and enrichment strategies (chemical biology/enrichment strategies preferred)
- Familiarity with data independent acquisition (DIA)
- Excellent problem-solving skills and attention to detail
- Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds
- Ability to thrive in a fast-paced environment with evolving priorities
- Occasional weekend availability required (~1-2 hours)
Nice To Haves
- Experience with Thermo Orbitrap mass specs and Vanquish Neo LCs
- Experience with cell surface proteomics or chemical labeling approaches
- Familiarity with immunopeptidomics workflows (MHC-I/MHC-II)
- Experience with performing LC-MS/MS on low-input samples (single-cell, spatial proteomics, immunopeptidomics)
- Familiarity with high-throughput proteomics workflows, automation and sample multiplexing
- Understanding of protein chemistry, post-translational modifications, and quantitative proteomics
- Basic knowledge of bioinformatics tools or scripting (e.g., R, Python)
Responsibilities
- Prepare tissue and cell samples for mass spectrometry–based proteomics, including precise tissue dissection and cell pellet processing
- Execute established protein and peptide enrichment strategies, including cell-surface labeling and immunopeptidomics workflows
- Follow validated protocols for protein extraction and purification across a range of sample types
- Utilize automation to achieve a sample throughput at 96x plate format scale
- Learn Orbitrap Astral Zoom operation and troubleshooting
- Operate and maintain the Orbitrap Astral Zoom, including routine instrument calibration
- Follow established SOPs closely to ensure consistent, reliable instrument performance
- Work closely with the proteomics and cross-functional teams to keep sample processing on schedule
- Document methods and maintain SOPs to support consistent, reproducible results
- Communicate proactively, surfacing issues early rather than letting them surface downstream
Benefits
- Employee Stock Option Plan
- 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
- Employer Retirement Contributions to 401(k)
- Generous Paid Time Off
- Paid Maternity and Paternity Leave
- Health & Wellbeing Program
- Office Snacks and Beverages
- Regular Team Bonding Activities
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Associate degree
