Senior Research Associate – Scientist II, Molecular Biology & Viral Vector Platforms

Adicet Bio•Redwood City, CA

2d•Hybrid

About The Position

Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CARs), to facilitate durable activity in patients. This role accelerates cell and genome therapy research by enabling reliable generation, characterization, and improvement of lentiviral vectors used in discovery and preclinical studies. We are seeking a highly motivated Senior Research Associate / Associate Scientist (BS/MS) to advance lentiviral vector research with some early process development. This is a 100% bench-based, hands-on laboratory role focused on running, troubleshooting, and improving upstream and downstream LVV workflows to enable discovery and preclinical studies. Hands-on, bench role: This position is primarily lab-based and focuses on molecular biology, library design/generation for screening mammalian/phage display or related, lentiviral vector production, and T cell / immune cell workflows. Success in this role requires strong experimental execution, troubleshooting, and clear ELN documentation.

Requirements

B.S. + 4 years, M.S. + 2 years, or Ph.D. + 1–2 years (or equivalent) in Molecular Biology, Cell Biology, Immunology, Bioengineering, Biochemistry, or related field.
Strong molecular cloning and nucleic-acid workflows (vector design, Gibson/In-Fusion, plasmid prep, PCR/qPCR) with independent troubleshooting.
Library design/build for screening or display (mammalian/phage or related) and support of selection/screen workflows.
Lentivirus production in HEK293T/293T (transfection, harvest) plus titering/QC (qPCR/ddPCR, p24, and/or functional assays).
Strong mammalian tissue culture (aseptic technique, expansion, banking) and comfort in BSL-2.
High experimental rigor, clear ELN documentation, and ability to run multiple experiments in parallel.

Nice To Haves

T cell activation, lentiviral transduction, expansion, and flow cytometry-based phenotyping/functional readouts.
NGS-enabled library readouts (barcoding strategies, sample prep coordination, and basic analysis partnership).
Viral vector scale-up/scale-down (cell factories, wave, or single-use bioreactors) and/or downstream handling (clarification/filtration, UF/DF, TFF)

Responsibilities

Design, build, and QC DNA constructs and variant libraries for screening (e.g., mammalian/phage display), including cloning strategy and library design influenced by structure-function analysis.
Produce, titer, and QC lentivirus from HEK293T or derivatives; optimize transfection and harvest conditions to improve yield/quality.
Perform mammalian tissue culture (maintenance, banking, transfection/transduction) in BSL-2; support scale-up as needed (cell factories and/or single-use bioreactors, where applicable).
Execute immune cell workflows as applicable (PBMC/T cell isolation, activation, gene delivery, expansion) and support functional characterization.
Run qPCR/RT-qPCR and multi-parameter flow cytometry; analyze results, troubleshoot, and recommend next experiments.
Maintain rigorous ELN documentation and follow EHS/BSL-2 practices for viral vectors and human-derived materials.
Leveling will align with experience (Senior Research Associate through Scientist) and demonstrated hands-on capability in molecular biology, library generation/screening, lentivirus, and cell culture/immune cell workflows.