Senior Research Associate, Novel Delivery Technologies (Contract)

Tessera Therapeutics • Somerville, MA

6d

About The Position

This role involves assisting in the development of an extrahepatic LNP delivery vehicle to support the delivery of editing payloads in vivo. The position will focus on formulation discovery and platform development activities, including the characterization of lipid nanoparticles (LNPs) for size, polydispersity, concentration, encapsulation, RNA, and protein content. The associate will execute experimental plans, interpret results with guidance, troubleshoot lab workflows, maintain equipment, and provide high-quality documentation. Collaboration with process development, analytical development, biology, and pharmacology teams is essential. The ideal candidate is a driven, enthusiastic, and self-motivated individual comfortable multitasking and working independently within a dynamic and highly collaborative team focused on the design and implementation of RNA Lipid Nanoparticle (LNP) delivery vehicles. Tessera employees are characterized as creative and collaborative problem solvers with a strong sense of integrity and an unwavering commitment to scientific excellence.

Requirements

• A Bachelor's degree in Chemistry, Chemical Engineering, Bioengineering, or related discipline and 2-4 years of experience, or a Master's degree in these fields with 1-2 years of experience.
• Prior experience with either of the following: Working with lipid nanoparticles (LNPs), including their manufacture and characterization. Implementing various bioconjugation techniques.
• A track record of planning experiments and completing deliverables within specified timelines.
• Excellent communication/presentation skills and capability of conveying technical information in a clear and thorough manner.
• A strong self-starter with excellent organizational skills and a strong attention to detail.
• The ability to work with dynamic teams in a fast-paced, entrepreneurial, and technical setting.

Nice To Haves

• Industrial research experience is preferred.
• Knowledge of nucleic acid chemistry and biology
• Prior experience with various protein characterization techniques
• Experience with lipid nanoparticle process scale up/down
• Process development and/or analytical development experience

Responsibilities

• Assisting in the development of an extrahepatic LNP delivery vehicle to support delivery of editing payloads in vivo.
• Assisting with experimental design and execution of formulation discovery and platform development activities.
• Performing characterization of LNPs to determine size, polydispersity, concentration and encapsulation using established techniques.
• Performing characterization of LNPs to determine RNA and protein content.
• Executing experimental plans and interpreting the results with guidance from senior scientists.
• Troubleshooting lab workflows and maintaining lab equipment.
• Providing high quality results and maintaining high quality documentation in lab notebooks.
• Collaborating effectively with process development, analytical development, biology, and pharmacology teams.

Benefits

• The stated pay range represents Tessera’s good-faith estimate for this role. Actual compensation will be determined based on a number of factors, including but not limited to individual qualifications, years of relevant experience, internal compensation alignment, and external market data.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior