Senior Research Associate, In Vivo Biology

Flagship Pioneering•Cambridge, MA

9d•Onsite

About The Position

Prologue Medicines are seeking a highly motivated and detail-oriented Senior RA to join our dynamic In Vivo Biology team, leading projects in discovery and pre-clinical development for therapeutic proteins of viral origin. The successful candidate will play a key role in designing, executing, and analyzing in vivo studies to evaluate therapeutic proteins with the aim of nominating development candidates, and supporting preclinical development and translational science of these molecules through to IND and beyond. As a member of our team, you will be responsible for designing and executing experiments to understand the activity, mechanism of action, and therapeutic potential of early-stage biologics in vivo. This role offers the opportunity to work in a dynamic, fast-paced, entrepreneurial environment, working independently as well as collaboratively within a highly integrated team. This is an on-site role in Somerville, MA.

Requirements

Bachelor’s or MS degree with 3+ years of relevant experience with in vivo and ex vivo lab experiments in accademia or industry.
Extensive experience with mouse handling: injections (IV, IM, IP), blood collection, and tissue harvesting is essential.
Performing and recording animal health observations, communicating adverse findings to the veterinarian technicians to ensure animal care standards are in keeping with applicable laws and regulatory guidelines.
Writes and maintains animal protocols.
Experienced with various ELN and LIMS systems.
Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner, document results in laboratory notebooks.
Demonstrated ability to work in a highly collaborative team environment.
Motivated and excited about biological discovery and assay development.
A dynamic problem solver and self-starter

Nice To Haves

Hands on experience in a variety of ex vivo / in vitro analysis techniques such as ELISA, MSD, Luminex, ELISpot, and flow cytometry from a wide range of different tissue types.
A proven track record of developing and optimizing disease efficacy models in mice.

Responsibilities

Planning, execution, and analysis of in vivo experiments to evaluate the therapeutic potential of our test articles including pharmacokinetic/pharmacodynamic, biodistribution, and efficacy studies.
Conducting ex vivo wet lab experiments to analyze PD phenotypes and MoA in different tissues.
Ability to work independently and as part of a collaborative team to design, plan and execute experiments, and manage outcomes to support research activities, project goals, and platform development.
Creative and strategic contributions to the discussions, designs, and implementation of in vivo and ex vivo
Managing relationships with external research facilities.
Reporting results to the scientific team and management.
Critical data analysis, attention to detail, and troubleshooting abilities.
Maintaining an organized and up-to-date electronic lab notebook.
Writing, updating, and maintain high-quality experimental protocols.