Sra 3

University of California, San Francisco•San Francisco, CA

About The Position

The Gaensler Lab at UCSF is seeking a highly skilled and motivated Senior Research Associate III (SRAIII) to contribute to our translational and pre-clinical studies focused on a novel leukemia vaccine. The lab's mission is to enhance anti-leukemic immunological responses in older patients with acute myelogenous leukemia, with the ultimate goal of improving relapse-free survival rates. The successful candidate will assess immunological responses to engineered human leukemia vaccines, collaborate on mechanistic studies of the tumor microenvironment, and participate in IND related studies.

Requirements

Proficiency in cell culture and cloning.
Experience with western blotting and protein expression is considered an additional asset.
Background in bioinformatics- single cell analysis highly desirable
Strong background in cellular biology, immunology including flow cytometric analyses .
Ability to manage multiple projects and work collaboratively in a dynamic research environment.
BA/BS degree in Biochemistry or related science and three or more years of recent, directly related work experience, utilizing the techniques or methods required by the position and demonstrating technical expertise in these areas; and/or equivalent experience/training.
Tissue Culture and all related skills, banking cells, aseptic technique.
Molecular biology techniques such as cloning, nucleic acid purification and analysis.
Good communication and good record keeping, organizational skills.

Nice To Haves

Experience with western blotting and protein expression is considered an additional asset.
Background in bioinformatics- single cell analysis highly desirable
Generally experienced in job duties and in the principles and practices associated with those duties with an understanding of the underlying scientific principles.
Ability to draft routine reports and keep accurate records of work performed.
Actively seeks opportunities to increase skills and expertise.
Able to learn complex tasks with general instruction.
Able to use experience to perform a variety of new techniques.

Responsibilities

Research and validation, project leadership, cell culture and cloning, gene expression and analysis, murine model development, database management, data recording, laboratory management
Take on primary research responsibility for specific projects, particularly those involving vaccine response and drug development using in vitro biochemistry and cellular experiments.
Conduct extensive cell culture work and standard cloning procedures.
Perform gene expression studies and flow cytometric analysis of immune and tumor cell populations.
Develop and utilize murine models for immune therapeutic strategies.
Establish and maintain a formal database for necessary reagents and research sample banking.
Conduct experiments and accurately record critical data.
Prepare paperwork for new protocols, communicate, and coordinate between sites and laboratories to ensure projects run smoothly.
Ensure research projects run smoothly and are compliant with UCSF policies.
Specimen management: oversee specimen intake, proper handling, storage and routing for pathway of processing.
Establish and oversee maintenance of tissue bank.
Innovation: implement and explore new technology and methodologies for IND associated projects
Teaching: As new SOPs are developed and implemented, the SRA III will assist to educate and implement other lab members according to protocol.