Senior Research Associate II, Assay Productization (P-5128)

10x Genomics•Pleasanton, CA

4h•$109,500 - $148,100

About The Position

We are seeking a Senior Research Associate II to join the Assay Productization (AP) team to support the development and commercial launch of new Single Cell Genomic products. Assay Productization acts as the interface between R&D and Production, involved in all stages of product development from concept to post-launch activities. This cross-disciplinary role works closely with Molecular Biology, Chemistry, Microfluidics, QC, and Manufacturing to develop and validate novel reagents across the 10x product portfolio. At this level, you will be developing your ability to define and resolve technical problems through growing scientific competence and sound judgment. You will take ownership of key AP documents and deliverables, design experiments to test hypotheses, contribute to new process development, and represent AP and Operations interests on the projects you support. This role is well-suited for a scientist who has mastered day-to-day laboratory execution and is ready to take on greater ownership and project scope.

Requirements

BS in molecular biology, biochemistry, genetics, analytical chemistry, or a related field with 4+ years of relevant experience; or MS with 2+ years.
Solid working knowledge of molecular biology with hands-on experience in NGS library generation and data evaluation.
Proficiency with analytical techniques including qPCR, nucleic acid isolation, and instrumentation such as Bioanalyzers or Fragment Analyzers.
Demonstrated ability to perform and analyze complex, multi-step experiments independently, with diligent attention to planning, organization, hands-on technique, and record keeping.
Experience troubleshooting molecular biology-based assays and reagent issues.
Ability to take ownership of documentation, including drafting and processing documents through ECO workflows.
Strong collaboration and communication skills, with the ability to work effectively across scientific and operational teams.
Self-motivated with ability to prioritize and manage work without daily task direction.

Nice To Haves

Previous work with a variety of NGS sample preparation workflows. Strong preference for single cell and/or RNA-Seq workflows.
Experience working in a process or product development environment, with exposure to technology transfer to manufacturing and/or QC groups.
Experience working with new and untested reagents or contributing to novel assay development.
Familiarity with PLM/ERP systems such as Arena for document and parts management.
Exposure to new product introduction (NPI) or product development processes (PDP).
Experience designing and executing longer-duration studies such as stability or compatibility testing.

Responsibilities

Create NGS libraries from single cells, tissues, or isolated DNA/RNA using 10x instruments and consumables following established SOPs and R&D protocols.
Take ownership of many NPI documents across one or more projects, including pushing documentation through ECOs and into full production.
Train Operations staff on complex new processes and workflows, ensuring accurate and thorough knowledge transfer.
Design experiments to test hypotheses and develop new reagent or assay processes, with growing independence.
Own AP deliverables end-to-end on one or more projects, including independent troubleshooting of reagent issues.
Scope out and execute larger, longer-term projects such as reagent stability studies and guard banding studies.
Assist with new QC method development and implementation to assess reagent quality through analytical and functional testing.
Represent AP and Operations interests on cross-functional projects, contributing your perspective at team and stakeholder meetings.
Present your own work clearly to internal stakeholders, offering comments and suggestions on the work of peers.
Perform troubleshooting analysis of failed experiments and reagent issues, applying standard practices and good judgment to determine corrective actions.