Senior Research Associate, Histology

Arbor Biotechnologies•Cambridge, MA

5d•$85,000 - $95,000•Onsite

About The Position

Before any of our CNS gene editing programs can move toward the clinic, we need to see in tissue where an editor went, whether it reached its target, and what it did there. This role produces that evidence. You’ll run and quantify the histology assays on rodent and non-human primate tissue that our program teams use to decide what moves forward.

Requirements

Bachelor’s degree in biology, neuroscience, pharmacology, or a related field with 3+ years of industry experience, or a master’s degree with 1+ year.
Has developed, optimized, and run IHC, IF, or ISH/RNAscope assays; automated staining platform experience preferred.
Has worked with CNS tissue from rodent models; non-human primate tissue experience preferred.
Has performed quantitative image analysis of CNS histology or ISH readouts in HALO, QuPath, ImageJ/Fiji, or a comparable tool.
Has kept detailed experimental records and presented data to a project team.

Nice To Haves

Automated staining platform experience
Non-human primate tissue experience
Worked on gene therapy, gene editing, AAV, or CNS programs

Responsibilities

Develop, optimize, and run IHC, IF, and ISH/RNAscope assays on preclinical CNS tissue.
Process, stain, and image CNS tissue from rodent and non-human primate studies.
Quantify assay readouts in image analysis software such as HALO, QuPath, or ImageJ/Fiji.
Generate the histology data used to assess biodistribution, target engagement, pharmacodynamic activity, editing outcomes, and safety.
Analyze and graph results in GraphPad Prism and summarize them clearly for project scientists.
Plan histology endpoints and tissue readouts for in vivo studies with the study lead.
Present results in group meetings and cross-functional study discussions.
Troubleshoot assays, improve workflows, and keep experimental records and sample tracking accurate.