Senior Research Associate, Formulation

Stoke Therapeutics•Bedford, MA

8d•$99,000 - $108,000•Onsite

About The Position

We are seeking a highly motivated and detail-oriented Senior Research Associate to join our Early Development team focused on oligonucleotide-based therapeutics. This role offers a unique opportunity to contribute to the design and development of innovative drug formulations at the preclinical and early clinical stages. You’ll work closely with cross-functional teams to support formulation screening, in vitro and in vivo formulation preparation, and process development for novel oligonucleotide candidates. This position will report into Senior Principal Scientist, formulation lead.

Requirements

B.S. with 4 years of experience or M.S. with 2 years of experience in Chemistry or Organic Chemistry
Strong organizational skills and attention to detail
Excellent communication and teamwork abilities

Nice To Haves

Prior industry experience in oligonucleotide formulation and scale-up is desired
Sound knowledge of analytical chemistry and basic nucleic acid chemistry is preferred
Experience with UPLC, LCMS and formulation characterization instrument is desired
Hands-on experience with lab techniques such as pH adjustment, UV spectroscopy, endotoxin and physical property measurement; hand-on experience with HPLC/UPLC is a plus

Responsibilities

Support the design and execution of formulation studies for oligonucleotide drug products
Perform laboratory experiments in a safe and efficient manner and record research findings in ELN
Collaborate with analytical, process development, and manufacturing teams to ensure seamless tech transfer
Support analytical testing and interpretation of data related to physical and chemical stability
Contribute to the preparation of technical reports, presentations, and regulatory documentation
Stay current with scientific literature and industry trends in oligonucleotide formulation and delivery
Additional tasks as assigned