Senior Research Associate, DMPK

Revolution Medicines•Redwood City, CA

6d•Onsite

About The Position

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide. Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients. The Opportunity: As a key member of our dynamic DMPK lab team within DMPK under the non-clinical development and clinical pharmacology (NDCP) department, you will have responsibilities including, but not limited to:

Requirements

Bachelor’s or master’s degree in pharmaceutical sciences or a related scientific discipline, with 5+ years of industry experience for bachelor’s degree holders or 3+ years for master’s degree holders.
Hands-on experience in operating and maintaining LC-MS/MS systems.
Hands-on experience in LC-MS/MS method development and bioanalytical analysis.
Knowledge of biological sample preparation and extraction techniques for downstream LC-MS/MS analysis.
Hands-on experience in HPLC/UPLC method development.
Ability to customize and follow established assay protocols.
Ability to manage multiple laboratory and project tasks efficiently.
Ability to work effectively in a flexible, team-oriented environment.
Highly organized and detail-oriented, with excellent recordkeeping skills and the ability to adapt to a dynamic, fast-paced environment.

Nice To Haves

Previous hands-on experience in SCIEX QTRAP mass spectrometers.
Previous hands-on experiences on bioanalytical method development in compliance with regulatory requirements.
Working experience in DMPK lab.

Responsibilities

Develop LC-MS/MS methods and analyze in vivo and in vitro samples to support ADME, pharmacokinetic, efficacy, and toxicokinetic studies, etc.
Handle a variety of tissues, including tumors, from tissue homogenization through sample preparation for bioanalysis.
Perform data analysis, prepare experimental result reports, and upload data to electronic notebooks.
Conduct in vitro ADME/DMPK assays in biological matrices, including hepatocytes, microsomes, blood, and plasma, ect.
Support laboratory operations, including lab safety, LC-MS/MS instrument maintenance and troubleshooting.