Senior Research Associate, Discovery Pharmacology

Altos Labs•San Francisco, CA

About The Position

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. At Altos, your work will be at the heart of our mission to transform medicine by reversing disease and restoring cellular health. You will help develop a new generation of therapeutics rooted in an advanced understanding of cellular rejuvenation and resilience. We are currently seeking a highly capable and motivated Senior Research Associate to join our Discovery Pharmacology team. In this role, your primary focus will be supporting critical drug discovery and development projects by executing a wide range of biological and bioanalytical assays. We are looking for a dedicated team player who values collaborative success and open communication. Your expertise will directly advance our drug discovery campaigns across a diverse portfolio, making a significant impact on aging biology, rejuvenation, and the future of medicine.

Requirements

BS or MS in Molecular Biology, Cell Biology, Biochemistry, Bioengineering, or a related discipline, and a minimum of 5 years of industry experience in a drug discovery and/or development setting.
Strong expertise in technical methods in AAV gene therapy for cellular transduction assays (aseptic technique), genome titration (qPCR, ddPCR), transgene expression (RT-qPCR, ddPCR), and protein analysis (Western Blot, ELISA, and capillary electrophoresis).
Good understanding and hands-on experience developing and performing a wide range of analytical and bioassays with fluency in data analysis and application of statistical modalities.
Experience in state-of-art assay technologies such as MSD, HTRF, AlphaLISA, Luminex, etc.
Hands on experience in automation instruments and platforms (e.g. Bravo, Echo, I.DOT, Digital dispenser, etc.).
Proficient in documenting experimental design, analysis and interpretation of data in ELN.
Excellent data presentation, oral and written communication skills.
Detail-oriented, organized, flexible, and capable of multitasking in a fast-paced environment.

Nice To Haves

Experience working across diverse therapeutic modalities, including viral based gene therapy, mRNA-LNP or other nucleic acid therapeutics, and small molecules.
Background in the field of aging/rejuvenation biology.
Familiarity with assay qualification criteria, processes, and SOP authoring.

Responsibilities

Work both independently and collaboratively with the scientific manager to drive drug discovery and development projects.
Culture and maintain mammalian cells, manage reagents and working stocks in addition to contributing to general lab maintenance.
Design, optimize, automate, execute, and troubleshoot a range of assays, including cellular, biochemical, and complex in vitro bioassays.
Standardize and optimize assay protocols and draft assay SOPs.
Document assay methods, raw data, and results in an electronic laboratory notebook (ELN), ensuring reproducibility and data integrity.
Make presentations and present data at project team meetings to support decision making.
The responsibilities of this role are expected to require ~80% of time dedicated to benchtop science.