Senior Research Associate, Biologics

Triveni Bio•Watertown, MA

10d

About The Position

Triveni Bio is breaking new ground in the identification of novel disease targets – working at the convergence of human genetics, best-in-class antibody design, and precision medicine. We are pioneering a Mendelian genetics-informed precision medicine approach to develop functional antibodies for the treatment of immunological and inflammatory (I&I) disorders. Our lead antibody program (TRIV-509) targets kallikreins 5 and 7 (KLK5/7) to directly impact skin barrier function, inflammation, and itch – providing a meaningful and much needed potential treatment option for patients with atopic dermatitis and other barrier disorders. In all the work we do, we adhere to our core values: patient impact, bold and rigorous science, open collaboration, kindness & respect. Triveni Bio is in search of an innovative Sr. Research Associate to join our Biologics team. In this role, you will lead the development, optimization, and execution of cell-based assays to evaluate the potency and function of biologics within Triveni’s therapeutic pipeline. Your work will directly contribute to the validation of new treatments for inflammatory diseases. On a day-to-day basis, you will culture a wide variety of continuous cell lines and primary cells, conduct functional readouts, and analyze the resulting data to identify high-potential candidates. This is a unique opportunity to apply your expertise in cellular biology and assay development to directly impact cross-functional therapeutic development.

Requirements

Bachelor’s or Master’s degree in Cell Biology, Biochemistry, Molecular Biology, or a related field with 2+ years of relevant experience developing and troubleshooting cell-based assays for evaluating the potency and function of biologics.
Demonstrated expertise in mammalian cell culture, specifically managing both diverse continuous cell lines and sensitive primary cells.
Proven technical proficiency with Flow Cytometry, ELISA, and MSD assay platforms.
Strong data analysis skills.
Excellent organizational skills with a strict commitment to accurate ELN documentation and data integrity.

Nice To Haves

Prior industry experience working specifically with therapeutic antibodies.
Experience with monoclonal and bispecific antibodies.
Hands-on experience with AKTA chromatography systems and proficiency in standard purification techniques such as affinity and SEC.

Responsibilities

Design, develop, and optimize robust cell-based assays to evaluate biologics potency and mechanism of action.
Establish, culture, bank, characterize, and maintain a wide variety of mammalian continuous cell lines and primary cells.
Execute multiplexed and functional readouts using Flow Cytometry, ELISA, and Meso Scale Discovery (MSD) platforms.
Analyze, interpret, and present experimental data using software tools such as GraphPad Prism, FCS Express, etc.
Maintain rigorous documentation of experimental designs, protocols, and results in an Electronic Laboratory Notebook (ELN).
Collaborate with cross-functional preclinical teams to advance therapeutic pipelines.
Other duties as assigned.