Senior Research Associate, Analytical Development

Systimmune • Bothell, WA

2d • $70,000 - $90,000 • Onsite

About The Position

SystImmune is a clinical-stage biopharmaceutical company developing cancer treatments, including bispecific and multispecific antibodies and antibody-drug conjugates. The Senior Research Associate in Analytical Development will be a hands-on contributor to the characterization of antibody-based therapeutics. The role executes, troubleshoots, and helps optimize analytical methods for early- to mid-stage development, with a focus on UPLC, CE, and binding assays. It is a lab-centered position for an experienced BS- or MS-level scientist who is rigorous at the bench, works effectively in a dynamic, high-throughput setting, and wants to grow into method development and ownership of analytical workflows.

This is an onsite position in Bothell, Washington. The role works with upstream, downstream, and formulation teams in an integrated CMC environment and contributes to analytical lab infrastructure as the company scales.

Requirements

• BS with at least 5 years, or MS with at least 3 years, of relevant biotech or pharmaceutical industry experience in biologics analytical development or a closely related laboratory function.
• Strong hands-on proficiency with HPLC/UPLC (SEC, IEX, or RP) and/or CE (CE-SDS, cIEF) for therapeutic proteins, including routine troubleshooting.
• Hands-on experience with antibody binding assays such as ELISA, SPR, or BLI.
• Working knowledge of antibody structure, common post-translational modifications, and critical quality attributes (CQAs).
• Attention to detail, strong organizational skills, and ability to manage multiple studies in parallel amid shifting priorities.
• Good written and verbal communication skills and a record of effective teamwork.
• Comfort working in a fast-paced, evolving environment and willingness to take on new responsibilities.

Nice To Haves

• Prior experience in a GMP or QC release testing environment, or with method qualification and tech transfer.
• Familiarity with Empower, SoftMax Pro, ForteBio Data Analysis, or JMP.
• Interest in working in a mission-driven environment and building from the ground up.

Responsibilities

• Independently execute UPLC methods (SEC, IEX, RP), CE methods (CE-SDS, cIEF), and binding assays (ELISA, BLI) to characterize antibodies accurately and reproducibly.
• Support method optimization and qualification under the guidance of senior scientists, and contribute to developing new methods as needed.
• Generate data for cell line development, process development, formulation screening, comparability, and stability studies; manage sample tracking and testing schedules.
• Process, analyze, and summarize data; conduct first-pass interpretation and promptly flag unexpected results or trends to project scientists.
• Maintain accurate, complete, and timely documentation in electronic lab notebooks and data systems in line with good documentation practices.
• Perform routine instrument maintenance, calibration checks, and basic troubleshooting for UPLC, CE, plate readers, and BLI instruments; coordinate service and preventive maintenance.
• Prepare reagents, buffers, reference standards, and critical materials; manage analytical lab inventory and ordering.
• Draft method protocols, data summaries, and sections of technical reports for senior scientists to review.
• Collaborate with upstream, downstream, and formulation team members in an integrated CMC environment.
• Help build analytical lab infrastructure, including evaluating new consumables, templates, and workflows.

Benefits

• 100% paid employee premiums for medical, dental, and vision insurance.
• Short-term disability and long-term disability coverage.
• 401(k) plan with a 50% company match of up to 3% and a five-year vesting schedule.
• 15 PTO days per year.
• Sick leave.
• 11 paid holidays.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior