Senior Research Assistant

UT MD Anderson Cancer Center • Houston, TX

1d • Onsite

About The Position

Genetics is a basic science department located in the George and Cynthia Mitchell Basic Sciences Research Building at the world-renowned UT MD Anderson in the heart of the Texas Medical Center. The focus is on advancing knowledge of the molecular genetic mechanisms that regulate normal and abnormal cellular processes. The Senior Research Assistant will independently coordinate and conduct research projects while providing technical and operational support to two collaborative cancer biology laboratories (Romero and Vaishnavi). The position will perform advanced experimental studies in cancer biology, genetics, and molecular biology, with a strong emphasis on mouse models of cancer. The incumbent will also manage breeding strategies, genotyping, colony maintenance, and animal husbandry. The Senior Research Assistant will also support laboratory operations by developing standard operating procedures, coordinating workflows, maintaining equipment and inventories, and ensuring compliance with institutional safety and animal welfare requirements. The position will train and mentor students and laboratory personnel, maintain accurate research documentation, troubleshoot experimental challenges, and manage multiple projects with minimal supervision. Strong organizational skills, scientific rigor, initiative, and effective collaboration with investigators and trainees are essential. This position is well suited for an experienced researcher seeking a long-term role in a dynamic, multidisciplinary cancer research environment. The ideal candidate will possess a Master's Degree in Basic Sciences or a Medical Degree along with research experience supporting advanced cancer biology, genetics, molecular biology, and animal model studies. Strong experience with genetically engineered mouse models, tumor implantation studies, preclinical therapeutic interventions, mammalian cell culture, molecular biology techniques, genome engineering methods, laboratory operations, and mentoring laboratory personnel is highly preferred.

Requirements

• Bachelor's Degree Natural sciences or related field
• Three years Scientific or experimental research work experience
• One year Required experience with preferred degree

Nice To Haves

• Master's Degree Basic sciences
• Medical Degree
• Experience with genetically engineered mouse models
• Tumor implantation studies
• Preclinical therapeutic interventions
• Mammalian cell culture
• Molecular biology techniques
• Genome engineering methods
• Sequencing sample preparation
• Laboratory operations
• Mentoring personnel
• Cancer biology research support

Responsibilities

• Plan and execute experimental studies while evaluating, interpreting, and documenting results.
• Collaborate closely with Principal Investigators on lung and prostate cancer biology projects using genetically engineered mouse models, tumor transplantation models, and therapeutic intervention studies.
• Adopt new techniques and develop innovative experimental approaches to advance research objectives.
• Perform laboratory studies using flow cytometry, tissue culture, nucleic acid extraction, PCR, immunoblotting, immunocytochemistry, and immunohistochemistry.
• Prepare samples for sequencing-based analyses and next-generation sequencing workflows as needed.
• Conduct animal studies involving tumor cell injections, viral delivery, genotyping, drug administration, imaging, monitoring, and documentation of experimental progress.
• Perform necropsies and prepare tissues for histological and molecular analyses.
• Work with conventional and immunocompromised mouse models.
• Design and execute animal studies involving intraperitoneal injections, oral gavage, subcutaneous and orthotopic tumor implantation, environmental exposures, tracheal intubation, survival surgery, tissue harvesting, and tissue processing.
• Manage breeding strategies, colony maintenance, genotyping, and animal husbandry activities.
• Conduct independent laboratory projects utilizing molecular biology, cellular biology, protein biology, imaging, and data analysis techniques.
• Perform cloning, DNA and RNA extraction, qRT-PCR, in situ hybridization, RNA sequencing, and CRISPR editing procedures.
• Maintain mammalian cell cultures and perform growth, migration, colony formation, drug response, transfection, viral production, and viral infection assays.
• Execute western blotting, protein immunoprecipitation, immunostaining, and mass spectrometry-based assays.
• Utilize microscopy techniques for imaging and quantitative analysis.
• Perform RNA sequencing data analysis and support related bioinformatics workflows.
• Collaborate with laboratory members on experimental studies and research initiatives.
• Request, organize, and manage patient specimens and patient-derived materials.
• Present research findings at laboratory and departmental meetings as needed.
• Maintain accurate and detailed records of experimental data, procedures, and protocols.
• Develop and refine experimental techniques, methods, and standard operating procedures.
• Assemble, operate, troubleshoot, and maintain laboratory apparatus and equipment.
• Coordinate laboratory workflows and prioritize multiple concurrent research projects.
• Ensure compliance with institutional safety requirements and animal welfare regulations.
• Update and maintain laboratory inventories, stocks, and records for general and hazardous materials.
• Order, organize, and track laboratory supplies and materials.
• Support laboratory organization and operational efficiency.
• Maintain documentation required for research activities and regulatory compliance.
• Train and mentor students, junior staff, and laboratory personnel on research techniques and procedures.
• Provide guidance on best practices, protocol adherence, and research documentation.
• Assist with manuscript preparation and grant application activities.
• Help update and renew laboratory IBC and IRB protocols.
• Troubleshoot technical challenges and implement solutions to support research goals.
• Perform additional duties as assigned.

Benefits

• Employer-paid medical coverage starting day one for employees working 30+ hours/week
• Optional group dental, vision, life, AD&D, and disability insurance.
• Accruals for PTO and Extended Illness Bank
• Paid holidays
• Wellness
• Childcare
• Other leave options
• Tuition Assistance Program after six months of service
• Access to extensive wellness, fitness, and employee resource groups.
• Defined-benefit pension through the Teachers Retirement System
• Voluntary retirement plans
• Employer-paid life and reduced salary protection programs.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior