Senior Project Manager, Biologics R&D - Early Pipeline Programs

Xaira Therapeutics•South San Francisco, CA

3d•$148,000 - $185,000•Onsite

About The Position

Xaira Therapeutics is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London. We are seeking a Project Manager, Biologics R&D to support the planning and coordination of biologics programs and projects across our early pipeline, beginning with one of our prioritized programs and spanning additional discovery-stage programs, from early-stage discovery through lead optimization and lead selection, with growing support into IND-enabling studies as programs advance. This role is well-suited for a candidate with a strong scientific background who has transitioned into a project or program management role or who has taken on cross-functional project management responsibilities within research settings. The ideal candidate will have hands-on experience in biologics R&D, with the ability to manage timelines, track deliverables, and partner closely with scientific leads to keep projects moving forward. You will partner closely with Program Team Leads, who own program strategy and scientific direction, and your counterpart on the lead program to ensure consistent program management practices across the portfolio. This position emphasizes scientific understanding, team coordination, and milestone tracking, making it a strong fit for someone with a bench science background who has taken on increasing responsibility for project organization and cross-functional collaboration. This role is as comfortable managing single projects as they are multiple projects driving to the same program objective or milestone.

Requirements

Advanced degree (MS, PhD, or equivalent) in life sciences or a related field strongly preferred.
Minimum of 6+ years of industry experience, including hands-on biologics or drug discovery research with demonstrated project or timeline management responsibilities; 3+ years of project management or cross-functional project leadership within research settings preferred.
Experience supporting biologics discovery programs through stages such as target validation, hit discovery, and lead optimization; exposure to lead selection governance or IND-enabling workstreams (developability, nonclinical safety, early CMC) is a strong plus.
Solid understanding of biologics discovery processes; familiarity with downstream nonclinical, CMC, and regulatory components is a plus.
Strong analytical, planning, and organizational skills; able to translate complex scientific ideas into clear plans.
Excellent communication, time management collaboration, and stakeholder management skills.
Experience with basic project tracking tools (Smartsheet, Confluence, Google Workspace, etc).
Working familiarity with project and program management principles as defined by the Program Management Institute (PMI) or similar bodies. PMP, CAPM, or PMI-ACP certifications are a plus, but note hands on experience matters more than the credential itself.

Nice To Haves

Comfortable managing projects in a start-up environment which is fast-paced, cross-functional, and where processes are still being built.
Demonstrated ability to lead without authority and influence diverse teams.
Passion for science and dedication to improving patient outcomes through innovative biologics development.
Growth mindset with interest in advancing alongside programs as they mature toward IND-enabling development.

Responsibilities

Support day-to-day planning and coordination of biologics research programs, ensuring execution of key activities from discovery through lead selection and into IND-enabling work as programs advance.
Build and maintain project timelines that capture critical path, major milestones, dependencies, and deliverables across multiple concurrent programs at different stages of maturity.
Partner with scientific leads and functional stakeholders to align on scope, priorities, resources and progress.
Collaborate with scientific teams to define key project milestones, decisional experiments and translate into actionable, resource-informed timelines, including stage-transition criteria such as hit-to-lead and lead selection.
Help compile project data, timelines, risks, value-realization, and trade-offs to support informed decision-making.
Coordinate and facilitate planning and documentation of decisive experiments, and update project plans based on results and next steps.
Facilitate cross-functional collaboration across research to ensure effective communication and documentation of decisions, alignment of priorities and timelines.
Schedule and run cross-functional meetings, ensuring clear agendas, effective documentation, and follow-up on action items.
Monitor interdependencies across functions and proactively identify, flag and resolve conflicts across workstreams.
Coordinate outsourced workstreams with CROs/CDMOs where applicable, including timeline integration and deliverable tracking.
Track project status, risks, and mitigation strategies; provide updates to internal stakeholders. Provide related insights and recommendations
Coordinate with functional leads to understand resource needs and potential impacts to timelines.
Contribute to scenario planning and contingency thinking for critical path activities
Identify operational challenges and recommend improvements to enhance efficiency and coordination.
Work closely with functional and team leads to understand resourcing needs, identify gaps and timeline impacts, including trade-offs across programs as well as within them.
Develop scenario plans for critical path development decisions to support contingency and investment planning to address potential delays, bottlenecks, or shifts in scope.