Senior Principal Statistical Programmer

WCG Clinical•Remote,

2d•$131,100 - $160,000•Remote

About The Position

The Senior Principal Statistical Programmer is a senior technical leader and subject matter expert in statistical programming, with deep expertise supporting clinical trials and Data Monitoring Committee (DMC) deliverables. The role combines advanced hands-on programming with technical leadership, including designing, developing, and standardizing high-quality statistical outputs. The position independently leads complex programming initiatives, provides expert guidance across projects, and helps shape programming standards, tools, and best practices. It partners with biostatistics, project management, data management, IT, and other stakeholders to deliver high-quality, compliant, and efficient programming outputs.

Requirements

Master’s degree required; in limited circumstances, an equivalent combination of education and directly relevant professional experience may be considered.
At least 8–10 years of statistical programming experience in a clinical trial environment.
Deep expertise in SAS programming, including complex analyses and regulatory deliverables.
Proficiency in R programming.
Demonstrated experience with CDISC standards and regulatory requirements.
Proven ability to independently lead complex programming efforts across studies.
Experience mentoring staff and driving technical standards or best practices.
Ability to independently coordinate biostatistical projects, including planning and oversight of programming activities, with minimal direction from senior leadership.

Responsibilities

Serve as a senior technical expert in statistical programming and provide guidance across multiple studies or functional areas.
Design, develop, validate, and oversee complex statistical programming deliverables, including analysis datasets, tables, listings, and figures.
Lead development, validation, and continuous improvement of DMC macros and programming standards.
Provide technical oversight and review of programming work to ensure quality, compliance, and consistency.
Establish and promote programming standards, best practices, and process improvements.
Collaborate with biostatistics and study teams on complex trial designs, analyses, and DMC reporting.
Manage and prioritize programming activities across multiple studies or initiatives.
Mentor statistical programming staff and support their skill development and use of best practices.
Contribute technical expertise to proposals, project planning, and scope discussions.
Partner with IT and technology teams on SAS environments, tools, and system validation efforts.
Provide technical oversight for programming activities that support regulatory submissions and inspection readiness.
Ensure programming deliverables align with regulatory expectations, submission requirements, and CDISC standards.
Influence programming approaches, standards, and best practices across studies or programs.
Serve as a technical escalation point and lead resolution of highly complex or ambiguous programming, data, or deliverable issues.
Interpret statistical analysis plans, protocols, and study documents, translating requirements into programming strategy.
Champion process improvements, automation, and innovative approaches to improve efficiency, scalability, and consistency.
Perform other duties as assigned by the supervisor.