Senior / Principal Scientist, Biochemistry

Treeline Biosciences • Watertown, MA

2d • Onsite

About The Position

About Treeline Treeline Biosciences is an innovative biotechnology company, founded by an experienced team of biopharmaceutical scientists and executives, committed to developing new medicines against difficult to drug targets in cancer and other life-threatening diseases. We are pursuing a uniquely integrated approach that applies modern and emerging tools in genomics, lead discovery, medicinal chemistry, and computation to reduce the time and risks of drug discovery. About the Role We are seeking an experienced and enthusiastic biochemist to join our growing team. The successful candidate for the Senior / Principal Scientist, Biochemistry position will have a critical role in supporting Treeline’s drug discovery programs by collaborating closely with a multi-disciplinary team of biology, biophysics, structural biology, computational, and medicinal chemistry scientists to deliver high-quality results and drive small molecule drug discovery. Specifically, you will propose, design, and implement new biochemical assays to screen and characterize protein-small molecule and protein-protein interactions.

Requirements

• PhD in biochemistry or a related discipline with 5+ years of industry experience, or a comparable combination of postdoctoral training and industry experience.
• Strong knowledge and understanding of steady-state enzyme kinetics and binding assays.
• Experience in small molecule drug discovery, specifically biochemical assay development and characterization of small molecule inhibitors and protein–ligand binding interactions.
• Experience in a wide array of biochemical assays, both enzymatic and binding, such as FP, TR-FRET, AlphaLISA, DSF.
• Experience with validating hits coming from DEL screening campaign
• Strong attention to detail, with excellent troubleshooting and problem-solving skills.
• Strong written and oral communication skills, excellent interpersonal skills, with demonstrated ability to work collaboratively on multidisciplinary teams.

Nice To Haves

• Knowledge of automation and experience with assay validation for HTS is beneficial.
• Experience using numerical simulations for experiment set up and data analysis
• Experience in working with challenging proteins.
• Working knowledge of adjacent disciplines (biophysics, structural biology, protein purification, biology, chemistry).
• General knowledge of signaling pathways, protein homeostasis, and regulation of gene expression beneficial.
• Track record of publications in high-impact scientific journals.

Responsibilities

• Propose, design, and implement biochemical assays for compounds testing and mechanism-of-action studies.
• Lead from the bench to propose and develop new assays and drive hit identification, hit-to-lead, and lead optimization experiments in collaboration with a cross-functional project team.
• Design and conduct high-quality scientific experiments.
• Apply biochemical methods to enable mechanistic studies and determine the mode of inhibition for promising hits.
• Analyze, interpret, and communicate high-quality data to a cross-functional project team.
• Collaborate with chemistry, biology, lead discovery, and medicinal design teams to characterize and establish SAR, rapidly advancing the hit-to-lead process.
• Propose and evaluate new approaches and technologies.
• Provide scientific leadership, mentorship, and cross-functional partnership within a dynamic matrixed environment.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree