Senior Principal Scientist/Associate Director PK Sciences (DUAL LEVEL POSTING)

Novartis•San Diego, CA

8d•Hybrid

About The Position

Senior Principal Scientist / Associate Director, PK Sciences, Therapeutic Areas (DUAL LEVEL POSTING) #LI_Hybrid Location: Cambridge, MA or San Diego (US) We are seeking an enthusiastic and motivated PK Sciences project team representative to develop and implement translational or clinical pharmacology strategies to support the pursuit of transformative new medicines through late clinical development. Our unique organizational structure enables colleagues to work seamlessly in the translational and/or clinical space, offering opportunities for development and bench-to-bedside-to-bench translation. Experience in late discovery and/or clinical area is preferred. The scope of the role potentially includes small molecules, biologics/therapeutic proteins, antibody drug-conjugates, radioligand therapies and/or cell therapies across major therapeutic areas in Novartis, including oncology, immunology, cardiovascular renal metabolism, neuroscience, and global health. This position drives close interdisciplinary collaboration among the PK Science disciplines, Drug Disposition (ADME, BA), Modeling & Simulation (M&S), and Operations through PK science sub-teams to achieve a holistic and integrative perspective of the ADME/clinical pharmacology properties of candidates and drugs

Requirements

Ph.D. / Pharm.D. with relevant experience
Preferred candidates will have a minimum of 5+ yrs at the Senior Principal Scientist Level and 8+ years at the Associate Director level) in clinical pharmacology, drug metabolism and pharmacokinetics or a related background in an industry setting.
Extensive and in-depth knowledge of pharmacokinetics including, drug metabolism and PK/PD evaluation, experience in working in project teams (preferably global) as well as sound awareness of recent developments in drug development and regulatory sciences.
Demonstrated success in working in a cross-functional, matrixed, project-team environment.
An influential Team player and talented negotiator with strong oral and written communication skills.
Proven record of mentorship and/or people management

Nice To Haves

Hands-on project experience with Artificial intelligence (AI) / Machine Learning (ML) approaches is a plus
Delivers results through disciplined execution, continuous improvement, and a strong focus on value and outcomes.
Demonstrates an enterprise mindset and strong ownership by prioritizing resources and decisions for maximum Novartis and patient impact.
Role models Novartis leadership behaviors through visible actions, continuous self reflection, and openness to feedback
Builds trust through transparent communication, clear accountability, and consistent delivery against commitments.
Empowers others to innovate and improve while maintaining high scientific, ethical, and operational standards.
Brings strong AI and digital fluency, using enterprise tools to enhance insight generation, decision making, and team productivity.
Accountable for the ethical, transparent, and compliant use of AI in line with Novartis AI governance and data protection standards.
Acts as an external thought leader, advancing Novartis’ reputation in translational science and innovation.
Drives operational excellence through disciplined execution, continuous improvement, and effective use of resources to maximize PKS and enterprise value.
Acts as a responsible steward of people, data, and digital capabilities, leveraging AI and automation to improve efficiency, quality, and decision speed.

Responsibilities

Independently represent the PK Sciences function in cross-functional project teams, interactions with stakeholders within the organization and interactions with regulatory agencies, as appropriate
Lead a PK Science Subteam with interdisciplinary representation of the major functions from within PK Science and beyond
Ensures implementation of project strategies and monitors timelines, objectives, and budgets for assigned projects
Present projects at various institutional review and approval boards
Proactively contributes to developing drug candidates across Research Development and Commercial continuum, providing expert pharmacokinetic / drug metabolism and clinical pharmacology input
Develop and execute clinical pharmacology strategies, including input into nonclinical and clinical study design, and analyzing PK and PK/PD data, to support compound development from discovery through late development
Provide PK, dosage, PK/PD and M&S component of study protocols, reports, project summaries and development plans, and author pharmacokinetic/clinical pharmacology/biopharmaceutics sections/radiation dosimetry of IND/IMPDs and NDA/BLAs as well as prepare appropriate responses to global Health Authority questions
Use of Artificial intelligence (AI) / Machine Learning (ML) approaches to enable model guided molecular design, preclinical and clinical data automation, authoring regulatory documents, and the use of predictive models
Is a mentor to or manages junior associates in the organization

Benefits

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits.
In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

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