Senior Oligonucleotide Chemist

Eurofins USA BioPharma Services•Lancaster, PA

1d•Onsite

About The Position

The Oligonucleotide Scientist is responsible for developing, optimizing, validating, and executing analytical methods to support oligonucleotide API, drug substance, and drug product testing. The role focuses primarily on HPLC/UHPLC and mass spectrometry (e.g., LC‑MS, LC‑MS/MS) for identity, purity/impurity profiling, quantitation, and stability-indicating assessments. The scientist will author methods, protocols and reports, ensure data integrity and compliance within GxP environments, and provide technical leadership for routine testing and investigations and mentoring of junior staff. Applies GMP in all areas of responsibility, as appropriate. Performing a large variety of analytical tasks for the validation of analytical methods used in the testing of drug products and raw materials by means of various procedures including HPLC, GC, UV/Vis, and dissolution. Reading, understanding, and interpreting diverse analytical procedures. Conducting analytical investigations. Troubleshoot instrumentation and communicate with vendors when required. Train and mentor junior staff in laboratory procedures. Manage and discuss projects with clients.

Requirements

Authorization to work in the U.S. indefinitely without restriction or sponsorship.
BS or MS degree in analytical chemistry or other related degree concentration.
BS and 4+ years of industry experience, MS and 2+ years of industry experience, or PhD and 1+ year of industry experience.
Industry experience with oligonucleotides and drug product testing.
3-5 years of experience with LC chromatographic validation in a GMP environment.
Excellent communication (oral and written) and attention to detail.
Ability to work independently and as part of a team, self-motivation, adaptability, and a positive attitude.
Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.

Responsibilities

Developing, optimizing, validating, and executing analytical methods to support oligonucleotide API, drug substance, and drug product testing.
Focusing primarily on HPLC/UHPLC and mass spectrometry (e.g., LC‑MS, LC‑MS/MS) for identity, purity/impurity profiling, quantitation, and stability-indicating assessments.
Authoring methods, protocols and reports.
Ensuring data integrity and compliance within GxP environments.
Providing technical leadership for routine testing and investigations.
Mentoring of junior staff.
Applying GMP in all areas of responsibility, as appropriate.
Performing a large variety of analytical tasks for the validation of analytical methods used in the testing of drug products and raw materials by means of various procedures including HPLC, GC, UV/Vis, and dissolution.
Reading, understanding, and interpreting diverse analytical procedures.
Conducting analytical investigations.
Troubleshooting instrumentation and communicating with vendors when required.
Training and mentoring junior staff in laboratory procedures.
Managing and discussing projects with clients.