Senior Medical Director - Biologics

AstraZeneca • Wilmington, DE

8d • $243,586 - $365,380 • Hybrid

About The Position

The US Senior Medical Director – Biologics provides US medical leadership for tezepelumab across severe asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, chronic obstructive pulmonary disease, and other areas of interest. As an integral member of the US Core Medical Team, the role is a primary US medical point of accountability for scientific strategy, evidence generation, and external engagement. The position aligns US medical strategy with global direction while responding to the US healthcare and clinical landscape.

Reporting directly to the US Medical Head of tezepelumab, the Senior Medical Director guides a high-performing team, drives launches, and helps connect evidence, access, and clinical practice to improve patient outcomes. The role is suited to a physician or pharmacist with relevant specialty expertise and experience in late-stage development, launch readiness, and post-approval medical affairs.

Requirements

• Doctoral degree (MD, PhD, MBBS, or PharmD).
• At least 3 years of demonstrated experience or strong expertise in respiratory medicine, allergy/immunology, or gastroenterology.
• Experience in late-phase clinical development and/or post-approval medical affairs.
• Well-developed understanding of the US regulatory environment, including FDA and OPDP.
• Excellent scientific communication, presentation, and customer engagement skills.
• Ability to travel an average of 25% within the US and occasionally internationally.

Nice To Haves

• Board certification or eligibility in Internal Medicine, preferably specializing in pulmonology, immunology and allergy, or digestive system disorders.
• Strong biologics and new product launch experience.
• Prior US pharmaceutical medical affairs experience, preferably in biologics.
• Experience supporting first-in-class, disease-modifying, or specialty products.
• Strong understanding of the US payer and provider landscape.
• Demonstrated success in cross-functional leadership and launch execution.

Responsibilities

• Lead US medical activities for tezepelumab and own development and execution of the US Brand Medical Plan across pre- and post-approval stages.
• Provide strategic medical input to US brand and launch strategy, aligning scientific priorities with patient and clinical needs.
• Translate biology, clinical data, and disease-state insights into actionable US medical strategies.
• Lead post-approval medical strategy to support appropriate scientific exchange and optimize patient care.
• Drive Phase 4 and lifecycle management strategy, including real-world evidence and effectiveness studies relevant to US clinicians and payers.
• Provide medical mentorship for US publication strategy and congress planning, and conduct medical review of promotional and non-promotional materials.
• Manage US publications and coordinate congress activities.
• Develop scientific response strategy and data dissemination.
• Serve as a US brand medical spokesperson as appropriate, including for external scientific discussions and media inquiries.
• Maintain the evolving US product scientific narrative using new data, guidelines, and real-world insights.
• Design and implement a US external engagement plan involving External Scientific Experts, academic institutions, and professional societies.
• Lead planning and participation in national and regional company-led advisory boards.
• Ensure high-quality, compliant scientific exchange that advances medical knowledge and education.
• Collaborate with medical evidence and payer teams to develop and implement clinical effectiveness studies, real-world evidence, and health outcomes research.
• Provide medical review and governance for Externally Sponsored Research proposals.
• Provide medical input into product safety strategy in collaboration with Patient Safety colleagues.
• Ensure compliance with US regulatory requirements, FDA standards, the PhRMA Code, and AstraZeneca policies.
• Provide clinical education and scientific training for the US Field Medical organization and cross-functional partners, including commercial, market access, and HEOR teams.
• Advise internal team members on disease strategy and emerging science.
• Collaborate with global medical and clinical teams, maintaining alignment while representing US medical needs.

Benefits

• Short-term incentive bonus opportunity.
• Eligibility to participate in an equity-based long-term incentive program.
• Qualified retirement program (401(k) plan).
• Paid vacation and holidays.
• Paid leaves.
• Medical, prescription drug, dental, and vision coverage, subject to applicable plan terms and conditions.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree