Senior Medical Director, Clinical Development
About The Position
Patients with adenoid cystic carcinoma (ACC) have waited decades for a treatment option. At Remix Therapeutics, we intend to change that. We are a clinical-stage biopharmaceutical company that has pioneered a new class of small molecule medicines targeting the RNA splicing machinery — correcting the disease-causing errors that drive ACC and other serious conditions at their source. REM-422 is our lead program, currently in clinical evaluation for ACC and AML/HR-MDS, and it is at a critical inflection point. Remix is building the team to bring this novel molecule forward for patients. This role is for a clinician ready to take on real medical ownership and help shape how REM-422 and future programs are developed. Reporting directly to the Chief Medical Officer at our Watertown, MA headquarters, you will work alongside senior leadership at a pivotal moment in the company's clinical trajectory, with direct visibility into how key development decisions get made. You will be a core contributor across a small, high-caliber cross-functional team where your judgment matters from day one. We are seeking someone with 5+ years of industry experience in oncology drug development and looking to grow as Remix scales.
Requirements
- MD or equivalent medical degree
- 5+ years of oncology clinical development experience within a biotech or pharmaceutical organization
- Hands-on experience as a medical monitor or clinical study physician, including SAE review and site oversight
- Familiarity with early-phase (Phase 1/1b) oncology trial design and execution
- Working knowledge of ICH/GCP guidelines and FDA regulatory requirements
- Strong scientific acumen with ability to engage deeply with translational data and biomarker-driven programs
- Excellent written and verbal communication; able to author clinical documents and synthesize complex data for varied audiences
Nice To Haves
- Experience with rare solid tumors, ACC, or head and neck oncology
- Exposure to hematologic malignancies (AML, MDS)
- Experience on biomarker-heavy or genomically-selected programs
- Familiarity with RNA or spliceosome biology
Responsibilities
- Serve as physician lead and medical monitor for REM-422 clinical studies, with direct accountability for patient safety, protocol adherence, and scientific and ethical rigor
- Review and assess SAEs, including narrative writing, causality assessment, and reconciliation with the safety database
- Respond to site medical queries, review eligibility exceptions, and support investigators on protocol requirements and deviation management
- Author and revise clinical documents including protocol synopses, IB sections, ICFs, and CSR narratives
- Interpret evolving clinical data — including safety trends, PK/PD signals, and emerging biomarker findings — and bring forward clear recommendations to the CMO and senior clinical team
- Support FDA and other agency meeting preparation; contribute medical sections to regulatory filings and briefing documents
- Collaborate with Clinical Operations on site selection, patient recruitment strategies, and trial execution
- Work closely with Pharmacovigilance, Biostatistics, and Regulatory Affairs to ensure aligned cross-functional execution
- Partner with KOLs, CROs, and investigators; provide medical input on vendor deliverables, data collection tools, and medical coding
Benefits
- bonus
- equity
- benefits
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
