Senior Manager, Commercial Supply Chain

Mirum Pharmaceuticals•Foster City, CA

8d•$180,000 - $190,000•Hybrid

About The Position

Mirum Pharmaceuticals is seeking an experienced, highly motivated, and detail-oriented Senior Manager, Commercial Supply Chain to support its growing global commercial portfolio and new product launches. The position is primarily responsible for domestic and international commercial distribution, inventory management, and order-to-cash operations to ensure timely, accurate, and compliant product delivery across global markets. The role also supports end-to-end commercial supply planning, including demand and supply alignment, labeling and packaging coordination, and finished product supply execution, while developing the capabilities to provide planning backup and maintain business continuity. The successful candidate will work with cross-functional teams and external supply chain partners to drive operational excellence, maintain uninterrupted commercial supply, and support patient access.

Requirements

Bachelor’s degree in Supply Chain Management, Business Administration, Operations Management, Logistics, or a related field.
At least 8 years of progressive experience in commercial supply chain, distribution, logistics, inventory management, or order-to-cash operations in the pharmaceutical or biotechnology industry.
Experience managing domestic and international commercial distribution operations, including 3PL providers and external distribution partners.
Strong understanding of order-to-cash processes, including customer order management, order fulfillment, inventory allocation, shipment execution, and reconciliation.
Working knowledge of pharmaceutical Good Distribution Practices, Good Manufacturing Practices, and applicable regulatory and distribution requirements.
Experience with international logistics, import/export requirements, customs clearance, Incoterms, and temperature-controlled pharmaceutical transportation.
Experience collaborating with Commercial Operations, Finance, Quality, Regulatory Affairs, and external supply chain partners.
Ability to independently manage complex operations, resolve supply chain issues, and drive process improvements.
Experience managing CMOs, CPOs, and multiple global 3PLs.
Knowledge of end-to-end commercial supply planning, including demand and supply planning, inventory projections, and supply-demand reconciliation.
Experience supporting global pharmaceutical product launches and commercial supply chain expansion.
Strong organizational and time-management skills, attention to detail, and ability to manage multiple priorities and meet tight deadlines.
Excellent analytical, problem-solving, and decision-making skills, including proactively identifying supply chain risks and implementing solutions.
Strong communication, interpersonal, and cross-functional collaboration skills; ability to manage external partners and influence stakeholders without direct reporting authority.
Ability to work independently, take ownership of operational deliverables, and drive continuous improvement.
Understanding of end-to-end commercial supply chain processes and interdependencies among demand and supply planning, manufacturing, labeling and packaging, inventory management, and distribution.
Ability and willingness to develop broader end-to-end commercial supply planning expertise to provide operational backup and ensure business continuity.
Integrity, accountability, adaptability, and a proactive, hands-on, team-oriented approach; ability to thrive in a small, dynamic organization.

Nice To Haves

Experience with advanced supply planning systems such as Kinaxis RapidResponse.
ASCM CPIM certification.
Demonstrated project management and negotiation skills.
Experience supporting new product supply chain planning.
Familiarity with pharmaceutical serialization, track-and-trace, and market-specific distribution requirements.
Experience establishing operational KPIs, conducting external partner business reviews, and leading continuous improvement initiatives.

Responsibilities

Lead domestic and international commercial distribution operations to ensure timely, accurate, and compliant product delivery.
Oversee order-to-cash activities, including customer order management, inventory allocation, order fulfillment, shipment execution, and reconciliation with Commercial Operations and Finance.
Manage commercial finished goods inventory across North American third-party logistics providers, including inventory reconciliation, product availability, replenishment, and shelf-life management.
Manage the operational performance and relationships of 3PLs, distributors, and logistics partners, including KPI development and monitoring, business reviews, and issue resolution.
Support new product launches, market expansion, distribution network readiness, supplier qualification, and implementation of new distribution partners.
Collaborate with Quality and cross-functional teams on distribution compliance and applicable deviation investigations, change controls, CAPAs, and other quality activities.
Improve distribution, inventory management, and order-to-cash processes through standardized procedures, system enhancements, and operational efficiencies.
Support end-to-end commercial supply planning by aligning demand, manufacturing, labeling and packaging, inventory, and distribution.
Work with CMOs, CPOs, and cross-functional teams to monitor manufacturing and packaging schedules, component availability, finished product readiness, and supply execution.
Support inventory projections, replenishment planning, supply-demand reconciliation, and proactive identification and mitigation of supply risks.
Participate in commercial labeling and packaging planning, including packaging readiness, market-specific supply requirements, and new product introductions.
Develop proficiency in end-to-end commercial planning processes, systems, and master data to provide backup support for supply planning and labeling and packaging activities.
Support supply chain transitions, business continuity, and continuous improvement initiatives, and stay informed of regulatory changes affecting commercial supply planning and distribution.