Senior Manager, Clinical Data Management
About The Position
CytomX Therapeutics is seeking a Senior Manager, Clinical Data Management to provide senior-level leadership for clinical data management across assigned studies or a complex clinical program. The role helps ensure trial data are accurate, complete, and available to support study objectives and informed decision-making. The position partners with internal study teams and external data management providers from study startup through study closure. Near-term work may include leading complex database changes or migrations, establishing integrated data-management plans, overseeing data review and vendor execution, and delivering timely, high-quality clinical data packages for key development decisions. The position is based in a hybrid work arrangement, with the primary location in Emeryville, California, and requires 10% travel. It is a full-time, exempt role reporting to the Executive Director, Clinical Data Management. The expected California salary range is $175,000–$205,000 per year, with offer amounts based on experience, qualifications, geographic location, and other job-related factors permitted by law. CytomX Therapeutics develops cancer treatments using its PROBODY® therapeutic platform. Its pipeline includes therapeutic candidates across antibody-drug conjugates, T-cell engagers, and immune modulators, with clinical-stage candidates CX-2051 and CX-801. The company describes a collaborative workplace focused on open communication, integrity, innovation, and patient impact.
Requirements
- Bachelor’s degree in a clinical, biological, mathematical, or related scientific field, or an equivalent combination of relevant education and experience.
- 6–8 years of clinical data management experience in the biotechnology, pharmaceutical, or clinical research industry.
- Experience independently leading clinical data management across multiple studies or a complex clinical program through major lifecycle milestones.
Nice To Haves
- Extensive experience with electronic data capture systems, including database development and oversight, user acceptance testing, data review, query management, complex amendments or migrations, and database lock activities.
- Experience providing comprehensive oversight of clinical data management work performed by CROs or other external service providers, including scope, quality, timelines, resources, and risk management.
- Working knowledge of clinical drug development, ICH, Good Clinical Practice, and applicable clinical data management requirements.
- Demonstrated ability to resolve complex data and operational issues, manage competing priorities and resources, influence cross-functional stakeholders, and communicate recommendations to senior leaders.
- Experience supporting oncology clinical trials.
- Experience with Medidata Rave or a comparable electronic data capture platform.
- Experience with database migrations, significant database amendments, or integrated clinical systems.
- Experience with IRT development or IRT-to-EDC integrations.
- Experience preparing data for regulatory submissions or health-authority interactions.
- Experience leading clinical data management procedures, standards, inspection readiness, audits, or corrective actions.
- Advanced degree in a relevant field.
Responsibilities
- Provide senior-level clinical data management leadership across a portfolio of assigned studies or a complex clinical program from study startup through database lock and study closure.
- Provide strategic and operational oversight of contract data management providers, including scope, deliverables, quality, timelines, resources, risks, and issue resolution.
- Lead the development, review, and approval of case report forms, CRF completion guidelines, edit-check specifications, data-transfer specifications, report specifications, and other study-specific data management documentation.
- Direct the development, testing, maintenance, and modification of clinical study databases and associated system integrations, including complex amendments and migrations.
- Establish the user acceptance testing approach and lead cross-functional testing of clinical databases and integrations.
- Represent Clinical Data Management in protocol development, integrated study planning, risk assessment, project timelines, and other relevant study or program documents.
- Define and oversee risk-based data-review strategies to identify errors, trends, discrepancies, and incomplete data in a timely manner.
- Lead cross-functional resolution of significant data-quality, reconciliation, and operational issues with sites, vendors, and internal stakeholders.
- Prepare and deliver high-quality clinical data packages for study-team and governance reviews, safety evaluations, regulatory deliverables, publications, and other approved uses.
- Independently analyze complex study and operational issues, determine or recommend solutions, and escalate significant program, compliance, resource, or business risks as appropriate.
- Communicate complex study status, data-quality findings, risks, dependencies, and recommendations to functional leadership, cross-functional partners, and senior stakeholders.
- Lead complex database amendments, migrations, and upgrades in accordance with approved study requirements and change-control processes.
- Perform other responsibilities consistent with the scope of the role and business needs.
Benefits
- Learning curriculum and career guidance to support development and career growth.
- Competitive total rewards program intended to support compensation goals and work/life balance.
- Collaborative work environment focused on shared goals and patient outcomes.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
