Senior Manager, 340B Optimization

BMC Software•Boston, MA

8d•$122,000 - $177,000•Onsite

About The Position

The individual is responsible for leading the strategic optimization, financial performance, and operational execution of the health system’s 340B program. This role serves as a system-level leader accountable for maximizing the value of the 340B program to expand patient access, improve affordability, and drive sustainable financial performance. This leader will partner across pharmacy, finance, compliance, and clinical operations to ensure accurate program execution, compliant growth, and continuous performance improvement across contract pharmacy, mixed-use settings, and eligible sites. The leader will also play a key role in translating 340B opportunity into actionable initiatives, ensuring alignment between program strategy, operational workflows, and financial outcomes.

Requirements

Bachelor’s degree in Pharmacy, Business, or related field
3-5+ years of progressive experience in pharmacy, with strong exposure to: 340B program management or optimization, Pharmacy operations (health system preferred), Financial and performance analytics
Experience within an academic medical center or large integrated delivery network.
Experience supporting specialty pharmacy, infusion services, or complex distribution models.
Experience presenting supply chain strategies and financial analyses to executive leadership and governance committees.
Or equivalent combination of education and experience.

Nice To Haves

PharmD or MBA preferred
Experience working in a complex health system or academic medical center strongly preferred
MA Pharmacist License
Knowledge of DSCSA compliance, pharmaceutical supply chain regulations, and drug shortage management frameworks – all related to 340B
Advanced analytical, financial modeling, and executive communication capabilities.

Responsibilities

Lead development and execution of a system-wide 340B optimization strategy aligned with organizational financial and access goals
Identify and implement opportunities to expand program capture, improve margin performance, and optimize contract pharmacy networks
Partner with executive leadership to translate 340B value into sustainable patient access strategies
Own performance tracking of the 340B program, including: Savings realization and margin optimization, Contract pharmacy performance, Capture rate and leakage analysis
Develop and maintain dashboards and reporting to support data-driven decision making
Partner with finance to ensure alignment between 340B performance and system financial targets
Oversee operational processes supporting 340B, including: Split-billing optimization, Eligibility workflows, Inventory and replenishment alignment
Identify and resolve operational gaps that impact program capture or compliance
Partner with pharmacy operations teams to ensure consistent execution across sites
Evaluate and optimize contract pharmacy network performance
Identify opportunities to: Improve financial yield, Enhance patient access, Reduce operational inefficiencies
Support development of contracting strategies and performance expectations
Partner closely with compliance leaders to ensure adherence to: HRSA requirements, State and federal regulations
Support audit readiness and remediation efforts
Ensure optimization strategies are designed with a compliance-first mindset
Collaborate with: Pharmacy operations (inpatient, outpatient, specialty), Finance and revenue cycle, Compliance and legal, IT / split-billing vendors
Serve as a key liaison to align stakeholders on 340B priorities and execution plans
Identify and implement innovative solutions to improve 340B performance (e.g., workflow redesign, technology enablement, analytics tools)
Support evaluation of new program opportunities, including: New site eligibility, Service line expansion, Enhanced patient engagement models
Provide direct oversight of analysts, managers, or program leads supporting 340B operations
Establish clear performance goals and accountability structures
Foster a culture of ownership, transparency, and continuous improvement
Support development of future leaders within the pharmacy organization