Senior Global Medical Director, CKM

GSK•Upper Providence, PA

About The Position

The Senior Global Medical Director provides strategic medical leadership for selected early indication-expansion and pipeline opportunities in cardio-renal-metabolic disease. The role ensures that Medical Affairs insights are incorporated into lifecycle strategy, population segmentation, clinical development, integrated evidence planning, scientific differentiation and launch readiness. It connects R&D, Global Product Strategy, Market Access, Evidence Generation and country Medical teams to develop a medically meaningful value proposition for patients, healthcare professionals, payers and health systems. The position also provides targeted Medical Affairs leadership to selected early cardio-renal-metabolic assets, supports the evolution of development and portfolio strategy, and ensures appropriate medical governance and compliance. The role operates across a global matrix and manages project-critical resources, vendors and budgets.

Requirements

MD/MBBS, PharmD or PhD in a clinical or scientific discipline.
Experience in cardio-renal-metabolic disease, including direct clinical or scientific work such as patient care, clinical research or relevant scientific programmes.
Medical Affairs experience at global and/or major-market level, with strategic responsibility for an asset or disease area.
Experience supporting all stages of clinical development, integrated evidence planning and lifecycle strategy, including study design, endpoint selection, data interpretation and post-approval evidence plans.
Experience translating external medical insights and complex clinical-trial, real-world-evidence and health-outcomes data into asset strategy, development decisions and executable medical plans.
Experience leading in a global matrix, influencing senior cross-functional stakeholders and driving decisions under ambiguity without direct line authority.
Experience managing concurrent projects, budgets, vendors and priorities in a fast-paced global environment and delivering high-quality outputs to agreed timelines.
Outstanding written and verbal communication skills in English, with a track record of distilling complex information into clear strategic recommendations for diverse audiences.

Nice To Haves

Experience with pre-launch and launch preparation at global and local levels, including evidence generation, scientific communications and omnichannel medical strategy.
Experience in patient segmentation, endpoint strategy, real-world evidence, health-outcomes research or implementation science.
Experience contributing to regulatory briefing documents, payer dossiers, guideline-shaping evidence or post-approval commitments.
Experience evaluating early assets or business-development opportunities and informing portfolio decisions in cardio-renal-metabolic disease.
Robust understanding of diverse healthcare systems, internal and external codes of practice, safety and regulatory requirements, and applicable industry standards.

Responsibilities

Lead global Medical Affairs strategy for assigned indication-expansion opportunities in alignment with asset strategy and portfolio priorities.
Provide senior medical input on indication sequencing, target populations, patient segmentation, desired medicine profiles, differentiation and scientific value propositions.
Partner with Clinical Development on study design, endpoints, data interpretation and the medical relevance of development choices.
Lead or co-lead integrated evidence planning, identifying and prioritising evidence gaps across clinical outcomes, patient-reported outcomes, real-world evidence, health outcomes, epidemiology, diagnostics, care pathways and implementation science.
Drive global scientific communications, including publications, congresses, advisory boards, scientific education and other channels.
Provide Medical Affairs leadership for selected early cardio-renal-metabolic assets, from candidate selection through Commit to Phase 3 or transition to asset-specific medical leads.
Profile patient pathways and treatment landscapes, define unmet needs, and identify evidence and education requirements that inform development and future clinical practice.
Build global matrix partnerships across R&D, Evidence Generation, Global Product Strategy, Market Access, Regulatory, Safety, Finance, Procurement and country Medical teams.
Align stakeholders on strategic choices and resolve competing priorities.
Manage project-critical resources, vendors and budgets to deliver milestones with quality and pace.
Ensure appropriate medical governance of strategies, studies, materials and activities, and compliance with the GSK Code of Practice, SOPs, external codes and regulations.