Senior Global Medical Affairs Lead CVRM

AstraZeneca • Gaithersburg, MD

2d • Hybrid

About The Position

Reporting to the Medical Head, the Senior Global Medical Affairs Lead Cardiovascular is a highly experienced Medical Affairs leader with proven vision and impact. This individual develops and leads bold medical strategies within the CVRM therapy area, expertly guiding cross-functional and cross-regional teams to deliver and exceed ambitious goals. The Senior GMAL’s influence is enterprise-wide—shaping global medical agendas through Global Medical Team, Global Product Team, and Disease Area Team leadership, and deep partnership with Medical and Commercial functions in markets and regions worldwide. This role demands a leader who champions innovative, disruptive thinking—identifies and shapes breakthrough opportunities, reimagines market dynamics, and accelerates high-impact evidence generation and medical change initiatives. The Senior GMAL navigates and transforms health systems, leverages digital and advanced analytics, drives stakeholder engagement, and ensures AstraZeneca’s science leads externally and internally through world-class medical evidence and strategic partnerships.

Requirements

• Minimum of Master’s degree or higher with at least 5 years of experience in the pharmaceutical industry (Medical, Marketing, R&D, Market Access), or extensive experience within a health system (clinical, pharmacy, pathway design, etc.).
• Demonstrated leadership in complex, global healthcare environments, including leading franchise/TA business in key markets, driving brand performance, and managing large, diverse teams including global launch of major products.
• Significant expertise and strategic insight into healthcare system pathways, regulatory landscapes, market-shaping, and external stakeholder engagement.
• Strong track record of internal and external network building, collaboration across geographies and matrix teams, and effective mentoring of junior colleagues or peers.
• Digital proficiency, leveraging digital health tools and data platforms to advance evidence generation and communication.
• Deep understanding of patient care pathways, evolving treatment protocols, scientific literature, and contemporary approaches to healthcare transformation.
• Proven ability to guide, influence, and align diverse stakeholders—including thought leaders, regulatory bodies, patient groups, and payer organisations.

Nice To Haves

• Doctoral-level degree (MD, PhD, PharmD) in a relevant discipline.
• Recognized expertise in the relevant or related therapeutic area, often evidenced by a history of clinical practice, research leadership, or significant external engagement.
• Advanced experience designing, leading, and interpreting clinical research programs, including pivotal clinical trials (Ph2–Ph4), practice-changing RWE studies, and implementation of innovative evidence generation approaches.
• Broad experience beyond Medical Affairs; for example, prior roles in Marketing, R&D, or Market Access.
• Long-standing relationships with global KOLs, societies, regulators, digital health partners, and innovative healthcare organisations.
• Track record of launching new products or indications in multiple, diverse markets (e.g., US, China, EU), and successfully developing and executing global medical strategies.

Responsibilities

• Designs and leads the implementation of product and disease area strategies, as well as ambitious practice change initiatives, at a global level.
• Consistently delivers innovative, disruptive solutions to shape markets, challenges status quo thinking, and uses digital proficiency to identify data-driven opportunities, preparing for launch and life cycle management.
• Owns the evidence generation strategy—demonstrating advanced experience in clinical research, interventional trials (Phases 2–4), and real-world evidence (RWE) programs.
• Shapes and drives groundbreaking clinical trials, registries, and RWE studies aligned with brand, access, and practice-changing objectives.
• Guides the optimisation, communication, and strategic roll-out of data across scientific platforms, ensuring AstraZeneca delivers differentiated evidence that supports the needs of regulatory, payer, and healthcare providers.
• Blends scientific expertise with strong digital acumen.
• Leverages digital health tools, advanced analytics, and data platforms to transform evidence communication, personalize stakeholder engagement, and enhance patient outcomes.
• Crafts compelling narratives, drives digital dissemination of evidence, and ensures accurate, impactful, and compliant scientific communications.
• Builds and sustains powerful relationships across the healthcare ecosystem—including global and regional KOLs, professional societies, regulators, payers, patient organizations, digital innovators, and health systems.
• Mobilizes support for medical strategy, evidence generation, and healthcare change initiatives.
• Mentors and guides cross-functional teams, championing scientific leadership and strategic collaboration.
• Ensures clinical trial and evidence generation initiatives are designed for both scientific and regulatory success.
• Anticipates evolving regulatory and payer requirements for evidence, ensuring high quality, compliant data generation and communication at every stage.

Benefits

• short-term incentive bonus opportunity
• equity-based long-term incentive program
• retirement contribution
• commission payment eligibility
• qualified retirement program [401(k) plan]
• paid vacation and holidays
• paid leaves
• health benefits including medical, prescription drug, dental, and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Senior