Senior Engineer: Mathematical Modeling and Simulation

Amgen • Cambridge, MA

3d • $115,495 - $156,257

About The Position

Amgen's Combination Product Operations Digital and Data Strategies group is a process development team that develops and deploys innovative advanced simulation technologies towards improved process understanding, robustness and monitoring, and prediction and optimization of the manufacturing of combination products. In this vital role you will support the team by incorporating physics and empirical techniques to develop rigorous finite element models (FEM) and numerical models of drug delivery devices (in-silico modeling assets) and improving the way Amgen manages and uses in-silico models to enhance decision making within the organization. The candidate will apply engineering principles to develop efficient and trustworthy models addressing a wide variety of challenging problems associated with advanced material modelling, device design, characterization, verification, validation, manufacturing and tolerance analysis. The ideal candidate enjoys tackling challenges and excels at developing functional in-silico models of combination products that enable insights for root cause investigation and design robustness supporting lifecycle management activities and complaint reduction.

Requirements

• Doctorate degree
• Master’s degree and 2 years of Engineering experience
• Bachelor’s degree and 4 years of Engineering experience
• Associate’s degree and 8 years of Engineering experience
• High school diploma / GED and 10 years of Engineering experience

Nice To Haves

• Finite element model experience with a commercial platform like SIMULIA, ANSYS, ALTAIR or COMSOL.
• Experience in explicit FEM modelling and non-linear structural models; contact modelling, large deformations, plasticity, and hyperelasticity.
• Knowledge of statistic and robustness analysis principles, being able to create models capturing the inherent variability in the process and device dimensions.
• Skilled in programming in Python, and/or MATLAB for engineering purposes. Scripting using commercial software codes like abaqus user subroutines, Tcl/Tk to automate model creation and post/processing.
• Experience with combination products and device regulatory requirements, medical device development and design controls, and knowledge of process controls.
• Excellent communication, presentation, and technical documentation skills are highly desired.
• Intellectual curiosity with ability to learn new concepts/frameworks, algorithms, and technology rapidly as needs arise.
• Ability to manage multiple competing priorities simultaneously and work in highly collaborative, cross-functional environments.

Responsibilities

• Implementing explicit and implicit FEM structural models. Ensuring that the approach and simplifications used to build these models is efficiently representing the physical system.
• Applying engineering principles like kinematic, structural, and tolerance analysis combined with material characterization and testing to create in-silico models able to capture the behavior of the device during use, assembly and transport.
• Continuous improvement of in-silico models, managing the lifecycle of the model and improving methods and workstreams to guarantee efficiency and trustworthiness of the models.
• Demonstrating critical and analytical thinking skills to explore new opportunities in in-silico and data-driven computational models. Modeling real-world scenarios with the adequate level of detail and help inform the decision making in a reduced time frame.
• Simulate complaints and real-world issues within lifecycle of combination products. Being able to apply an analytical approach to create models that accurately represent the real world scenarios and helps identify the root cause analysis of any complaint.
• Providing positive leadership and delivering work in a fast-paced, multi-project, cross-functional environment. Delivering predictions and insight on time to solve challenging production and customer problems.
• Model ownership, responsible for developing and managing backlog of in-silico product projects. Being able to concisely communicate on the modelling scope, limitations and assumptions to stakeholders with a technical and not technical background. Mentor also other simulation experts in the best use of simulation technologies.
• It is expected that the Senior Engineer – Modeling and Simulation will not only lead and collaborate heavily with internal team members, but also document and communicate the underlying technical basis of the models for the benefit of and use by the broader engineering and scientific community responsible for design and manufacture of drug delivery devices.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree