Senior Director, Translational Medicine

Revolution Medicines•Redwood City, CA

3d•$244,000 - $305,000•Hybrid

About The Position

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: To aid in this mission, the Translational Medicine team at RevMed is seeking a highly motivated, scientifically creative and collaborative Senior Director to work in a fast-paced environment within a cross-functional team. This role will report to the Head of Clinical Biomarker Development and will be leading the design and execution of clinical biomarker plans for RAS(ON) inhibitor clinical programs across solid cancer types. The position will serve as a subject-matter expert (SME) in clinical biomarker development and support clinical development strategy and programs through product life cycle.

Requirements

A Ph.D. in cancer biology, cell/molecular biology, genomics or equivalent with 10+ years of industry experience.
6+ years of experience in clinical biomarker development in oncology is required.
Development experience within oncogenic signaling pathways is required.
Broad knowledge and understanding of established and novel technologies employed in clinical diagnostic assays (e.g. NGS, IHC, PCR) are required.
Broad knowledge of utilizing local enrollment strategies for biomarker identification of patients.
Excellent scientific and business communication skills, strong interpersonal/collaboration skills and planning skills.
Ability to think critically and creatively and be able to work independently to determine appropriate resources for resolution of problems.
Ability to multi-task and thrive in a fast-paced innovative environment.
A great teammate, who listens effectively and invites response and discussion.
Commitment to Revolution Medicines’ Core Values: Tireless Commitment to Patients, Transformative Science, Exceptional Together, Total Integrity, Inclusiveness and Fairness.

Nice To Haves

Knowledge of RAS biology and mechanism of action of RAS inhibitors is preferred.
Prior experience within RAS-MAPK clinical development is highly desired.
Development experience across Phase 1 and Phase 3 clinical trials is desirable.

Responsibilities

Lead strategic, translational thinking and contributions to early and late-stage clinical development plans.
Represent Translational Medicine function on cross-functional teams at the program level.
Effectively collaborate with Clinical Development, Clinical Operations, Biostatistics, Biomarker Operations and Regulatory on study design and protocol development.
Partner with Clinical Bioinformaticians in developing biomarker analysis plans, as well as effectively collaborate with TM subfunctions of Clinical Biomarker Operations, Clinical Bioinformatics and Companion Diagnostics.
Collaborate with Clinical Development, Biostatistics, and Medical Affairs to develop plans for publication of clinical biomarker results.
Collaborate with Cancer Biology, Translational Research and Cancer Immunology to accelerate forward and reverse translational research.
Keep abreast in new developments in RAS biology, predictive biomarkers, and novel molecular assays, and share knowledge with functional and cross-functional team members.